Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 7/20 | 0.46 |
| ▸ | PPARG | P37231 | 3/20 | 0.45 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.44 |
| ▸ | CCR2 | P41597 | 2/20 | 0.44 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | TACR2 | P21452 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2005057 | 0.91 | PLA2G2A (0.44) | PLA2G2APPARGPTGDR2CCR2PLA2G10 | |
| SCHEMBL2003338 | 0.89 | CCR2 (0.45) | PLA2G2APPARGCCR2CYP2C9ALOX5 | |
| SCHEMBL15062617 | 0.86 | PTGDR2 (0.49) | PLA2G2APPARGPTGDR2PPARACYP2C9 | |
| SCHEMBL2002605 | 0.84 | PPARG (0.60) | PLA2G2APPARGPPARACYP2C9EGFR | |
| SCHEMBL3006501 | 0.81 | PTGDR2 (0.64) | PLA2G2APTGDR2CYP2C9ALOX5MAPT | |
| SCHEMBL2006786 | 0.79 | PLA2G2A (0.53) | PLA2G2APTGDR2 | |
| SCHEMBL15062618 | 0.78 | PLA2G2A (0.45) | PLA2G2APPARGPTGDR2PPARACYP2C9 | |
| SCHEMBL2996259 | 0.74 | PTGDR2 (0.60) | PLA2G2APTGDR2CYP2C9ALOX5MAPT | |
| SCHEMBL2009343 | 0.72 | PPARG (0.57) | PPARGPPARACYP2C9EGFRCHRM4 | |
| SCHEMBL2005221 | 0.71 | PTGDR2 (0.66) | PLA2G2APTGDR2CYP2C9ALOX5MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |