Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.46 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.41 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SCN1A | P35498 | 1/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20060882 | 0.92 | GPR119 (0.39) | GPR119SLC6A12NTRK1CHRM4UTS2R | |
| SCHEMBL20060849 | 0.88 | UTS2R (0.41) | GPR119KMT2AHPGDALDH1A1CHRM4 | |
| SCHEMBL22310514 | 0.87 | GPR119 (0.41) | GPR119KMT2A | |
| SCHEMBL20061055 | 0.86 | GPR119 (0.47) | GPR119HRH3 | |
| SCHEMBL20060927 | 0.86 | GPR119 (0.47) | GPR119HRH3 | |
| SCHEMBL20060883 | 0.85 | GPR119 (0.38) | GPR119 | |
| SCHEMBL22284450 | 0.84 | NR1H2 (0.46) | GPR119SLC6A12CRHR1KMT2AHRH3 | |
| SCHEMBL22311278 | 0.84 | NR1H2 (0.46) | GPR119SLC6A12CRHR1KMT2AHRH3 | |
| SCHEMBL22284448 | 0.84 | NR1H2 (0.46) | GPR119SLC6A12CRHR1KMT2AHRH3 | |
| SCHEMBL30451172 | 0.84 | NR1H2 (0.46) | GPR119SLC6A12CRHR1KMT2AHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018068295-A1 | ARYL AND HETEROARYL ETHER DERIVATIVES AS LIVER X RECEPTOR β AGONISTS, COMPOSITIONS, AND THEIR USE | MERCK SHARP & DOHME CORP. (US) | 2018-04-19 | — | — | WO | disclosed |
| WO-2018071317-A1 | ARYL AND HETEROARYL ETHER DERIVATIVES AS LIVER X RECEPTOR BETA AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2018-04-19 | — | — | WO | disclosed |