Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UTS2R | Q9UKP6 | 5/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | THRA | P10827 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20060844 | 0.88 | GPR119 (0.46) | UTS2RCHRM4KMT2AGPR119ALDH1A1 | |
| SCHEMBL20061055 | 0.87 | GPR119 (0.47) | THRATHRBGPR119 | |
| SCHEMBL20060927 | 0.87 | GPR119 (0.47) | THRATHRBGPR119 | |
| SCHEMBL22311054 | 0.85 | NR1H2 (0.48) | UTS2RSIGMAR1TMEM97SMN1; SMN2MEN1 | |
| SCHEMBL22311056 | 0.85 | NR1H2 (0.48) | UTS2RSIGMAR1TMEM97SMN1; SMN2MEN1 | |
| SCHEMBL30451273 | 0.85 | NR1H2 (0.48) | UTS2RSIGMAR1TMEM97SMN1; SMN2MEN1 | |
| SCHEMBL20060882 | 0.83 | GPR119 (0.39) | UTS2RCHRM4RAB9ATHRBGPR119 | |
| SCHEMBL22310514 | 0.83 | GPR119 (0.41) | RAB9AKMT2AGPR119CHRM2 | |
| SCHEMBL20060885 | 0.82 | PDK2 (0.41) | THRATHRBMCHR1GPR119 | |
| SCHEMBL20060889 | 0.81 | PDK2 (0.41) | MEN1NPC1RAB9AKMT2ATHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018068295-A1 | ARYL AND HETEROARYL ETHER DERIVATIVES AS LIVER X RECEPTOR β AGONISTS, COMPOSITIONS, AND THEIR USE | MERCK SHARP & DOHME CORP. (US) | 2018-04-19 | — | — | WO | disclosed |