Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 4/20 | 0.35 |
| ▸ | THRA | P10827 | 2/20 | 0.35 |
| ▸ | CNR1 | P21554 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | NAAA | Q02083 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 3/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20061075 | 0.77 | THRB (0.47) | THRBTHRAMEN1POLBKMT2A | |
| SCHEMBL9363634 | 0.76 | MAPT (0.40) | THRBTHRACNR1MEN1KMT2A | |
| SCHEMBL20060890 | 0.74 | POLB (0.47) | CNR1MEN1POLBKMT2AHPGD | |
| SCHEMBL20060900 | 0.72 | THRB (0.46) | THRBTHRAMEN1POLBKMT2A | |
| SCHEMBL8828641 | 0.67 | CNR1 (0.43) | CNR1MEN1KMT2AHPGDKDM4E | |
| SCHEMBL23838116 | 0.67 | HCAR3 (0.44) | CNR1MEN1KMT2AKDM4E | |
| SCHEMBL18838583 | 0.66 | CNR1 (0.43) | CNR1MEN1KMT2AHPGDKDM4E | |
| SCHEMBL22368333 | 0.66 | CNR1 (0.34) | CNR1MEN1KMT2AKDM4E | |
| SCHEMBL20077096 | 0.65 | CNR1 (0.42) | CNR1MEN1KMT2AHPGDKDM4E | |
| SCHEMBL22284325 | 0.65 | ITGB3 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018068295-A1 | ARYL AND HETEROARYL ETHER DERIVATIVES AS LIVER X RECEPTOR β AGONISTS, COMPOSITIONS, AND THEIR USE | MERCK SHARP & DOHME CORP. (US) | 2018-04-19 | — | — | WO | disclosed |
| WO-2018071317-A1 | ARYL AND HETEROARYL ETHER DERIVATIVES AS LIVER X RECEPTOR BETA AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2018-04-19 | — | — | WO | disclosed |