Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 10/20 | 0.38 |
| ▸ | HTR1A | P08908 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20060866 | 0.91 | GPR119 (0.44) | HCRTR1HCRTR2GPR119FFAR1 | |
| SCHEMBL20060927 | 0.82 | GPR119 (0.47) | GPR119 | |
| SCHEMBL20061055 | 0.82 | GPR119 (0.47) | GPR119 | |
| SCHEMBL20060864 | 0.81 | GPR119 (0.43) | GPR119 | |
| SCHEMBL22310514 | 0.81 | GPR119 (0.41) | GPR119KMT2A | |
| SCHEMBL20077051 | 0.81 | GPR119 (0.38) | GPR119KMT2A | |
| SCHEMBL20077739 | 0.80 | NR1H2 (0.38) | GPR119FFAR1 | |
| SCHEMBL20060844 | 0.79 | GPR119 (0.46) | GPR119KMT2A | |
| SCHEMBL20068519 | 0.79 | FFAR1 (0.43) | HCRTR1HCRTR2GPR119FFAR1 | |
| SCHEMBL20060883 | 0.79 | GPR119 (0.38) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018068295-A1 | ARYL AND HETEROARYL ETHER DERIVATIVES AS LIVER X RECEPTOR β AGONISTS, COMPOSITIONS, AND THEIR USE | MERCK SHARP & DOHME CORP. (US) | 2018-04-19 | — | — | WO | disclosed |