Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 13/20 | 0.73 |
| ▸ | RAB9A | P51151 | 13/20 | 0.73 |
| ▸ | MEN1 | O00255 | 4/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.72 |
| ▸ | PKM | P14618 | 4/20 | 0.72 |
| ▸ | MAOB | P27338 | 1/20 | 0.72 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.72 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.67 |
| ▸ | SCD | O00767 | 1/20 | 0.66 |
| ▸ | TP53 | P04637 | 2/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.62 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11703862 | 0.93 | NPC1 (0.83) | NPC1RAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL11703126 | 0.88 | NPC1 (0.79) | NPC1RAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL13076211 | 0.87 | NPC1 (0.73) | NPC1RAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL24845490 | 0.85 | RAB9A (0.76) | NPC1RAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL3926899 | 0.84 | NPC1 (1.00) | NPC1RAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7348401 | 0.84 | NPC1 (0.73) | NPC1RAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL31329354 | 0.84 | NPC1 (1.00) | NPC1RAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2248250 | 0.84 | NPC1 (1.00) | NPC1RAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL8558926 | 0.84 | RAB9A (0.81) | NPC1RAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL9963858 | 0.83 | RAB9A (0.76) | NPC1RAB9AMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11767298-B2 | Substituted benzimidazoles as inhibitors of transforming growth factor-β kinase | DUKE UNIVERSITY (US) | 2023-09-26 | — | — | US | disclosed |
| US-11767298-B2 | Substituted benzimidazoles as inhibitors of transforming growth factor-β kinase | DUKE UNIVERSITY (US) | 2023-09-26 | — | — | US | disclosed |
| US-20210188783-A1 | SUBSTITUTED BENZIMIDAZOLES AS INHIBITORS OF TRANSFORMING GROWTH FACTOR-BETA KINASE | DUKE UNIVERSITY | 2021-06-24 | — | — | US | disclosed |
| US-10927083-B2 | Substituted benzimidazoles as inhibitors of transforming growth factor-β kinase | DUKE UNIVERSITY (US) | 2021-02-23 | — | — | US | disclosed |
| US-20190263759-A1 | SUBSTITUTED BENZIMIDAZOLE AND BENZOTHIAZOLE INHIBITORS OF TRANSFORMING GROWTH FACTOR-BETA KINASE AND METHODS OF USE THEREOF | DUKE UNIVERSITY | 2019-08-29 | — | — | US | disclosed |
| US-10207998-B2 | Substituted benzimidazole and substituted benzothiazole inhibitors of transforming growth factor-β kinase and methods of use thereof | DUKE UNIVERSITY (US) | 2019-02-19 | — | — | US | disclosed |
| US-20180105500-A1 | NOVEL INHIBITORS OF TRANSFORMING GROWTH FACTOR KINASE AND METHODS OF USE THEREOF | DUKE UNIVERSITY | 2018-04-19 | — | — | US | disclosed |
| US-20180105500-A1 | NOVEL INHIBITORS OF TRANSFORMING GROWTH FACTOR KINASE AND METHODS OF USE THEREOF | DUKE UNIVERSITY | 2018-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190263759-A1 | SUBSTITUTED BENZIMIDAZOLE AND BENZOTHIAZOLE INHIBITORS OF TRANSFORMING GROWTH FACTOR-BETA KINASE AND METHODS OF USE THEREOF | TAB1, TGFBR1, SMAD2 | NPC1 3411/4885RAB9A 4205/4885MEN1 2746/4885 |
| US-10207998-B2 | Substituted benzimidazole and substituted benzothiazole inhibitors of transforming growth factor-β kinase and methods of use thereof | TAB1, TGFBR1, SMAD3 | NPC1 2287/4885RAB9A 4298/4885MEN1 2669/4885 |
| US-10927083-B2 | Substituted benzimidazoles as inhibitors of transforming growth factor-β kinase | TAB1, TGFBR1, CHUK | NPC1 2466/4885RAB9A 3596/4885MEN1 3250/4885 |
| US-20210188783-A1 | SUBSTITUTED BENZIMIDAZOLES AS INHIBITORS OF TRANSFORMING GROWTH FACTOR-BETA KINASE | TAB1, TGFBR1, CHUK | NPC1 2781/4885RAB9A 3655/4885MEN1 2955/4885 |
| US-20180105500-A1 | NOVEL INHIBITORS OF TRANSFORMING GROWTH FACTOR KINASE AND METHODS OF USE THEREOF | TAB1, BMP2K, SMAD3 | NPC1 2677/4885RAB9A 4012/4885MEN1 2966/4885 |
| US-11767298-B2 | Substituted benzimidazoles as inhibitors of transforming growth factor-β kinase | TAB1, CHUK, TGFBR1 | NPC1 2076/4885RAB9A 3987/4885MEN1 2265/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.