Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 2/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | FUCA1 | P04066 | 1/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.44 |
| ▸ | SSTR3 | P32745 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | EBP | Q15125 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TACR1 | P25103 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27010643 | 1.00 | KDM1A (0.47) | KDM1AMAOAFUCA1GRIN2BSSTR3 | |
| SCHEMBL2198525 | 0.88 | KDM1A (0.58) | KDM1AMAOAFUCA1GRIN2BSSTR3 | |
| SCHEMBL2936924 | 0.88 | KDM1A (0.58) | KDM1AMAOAFUCA1GRIN2BSSTR3 | |
| SCHEMBL2197644 | 0.88 | KDM1A (0.58) | KDM1AMAOAFUCA1GRIN2BSSTR3 | |
| SCHEMBL491107 | 0.88 | KDM1A (0.58) | KDM1AMAOAFUCA1GRIN2BSSTR3 | |
| SCHEMBL2197651 | 0.88 | KDM1A (0.58) | KDM1AMAOAFUCA1GRIN2BSSTR3 | |
| SCHEMBL2798417 | 0.88 | KDM1A (0.58) | KDM1AMAOAFUCA1GRIN2BSSTR3 | |
| Bromide SCHEMBL18129441 | 0.86 | KDM1A (0.56) | KDM1AMAOAFUCA1GRIN2BSSTR3 | |
| Bromide SCHEMBL17822680 | 0.86 | KDM1A (0.56) | KDM1AMAOAFUCA1GRIN2BSSTR3 | |
| Ammonia Solution, Strong SCHEMBL2987109 | 0.86 | KDM1A (0.56) | KDM1AMAOAFUCA1GRIN2BSSTR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200115354-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2020-04-16 | — | — | US | disclosed |
| US-10457654-B2 | Therapeutic compounds and methods of use thereof | GENENTECH, INC. (US) | 2019-10-29 | — | — | US | disclosed |
| US-20180105504-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2018-04-19 | — | — | US | disclosed |
| US-20180105504-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2018-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200115354-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | NPY5R, REN, F12 | KDM1A 2698/4885MAOA 3172/4885FUCA1 3782/4885 |
| US-10457654-B2 | Therapeutic compounds and methods of use thereof | NPY5R, REN, F12 | KDM1A 2698/4885MAOA 3172/4885FUCA1 3782/4885 |
| US-20180105504-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | NPY5R, REN, F12 | KDM1A 2873/4885MAOA 3140/4885FUCA1 3816/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.