Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | C3AR1 | Q16581 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10378518 | 0.82 | EPHX1 (0.50) | EPHX1KMT2AALDH1A1EPHX2GAA | |
| SCHEMBL27691760 | 0.82 | EPHX1 (0.50) | EPHX1KMT2AALDH1A1EPHX2GAA | |
| SCHEMBL578174 | 0.81 | TSHR (0.59) | EPHX1KMT2AEPHX2NPC1LMNA | |
| SCHEMBL8367638 | 0.80 | ALDH1A1 (0.57) | EPHX1KMT2APOLBMEN1ALDH1A1 | |
| SCHEMBL10378482 | 0.80 | ALDH1A1 (0.49) | EPHX1KMT2AALDH1A1MAPTNPC1 | |
| SCHEMBL10527496 | 0.79 | MAPK1 (0.61) | EPHX1POLBALDH1A1MAPTLMNA | |
| SCHEMBL10378525 | 0.78 | POLB (0.47) | KMT2APOLBMEN1ALDH1A1MAPT | |
| SCHEMBL2199200 | 0.75 | EPHX1 (0.54) | EPHX1KMT2APOLBMEN1ALDH1A1 | |
| SCHEMBL6781380 | 0.74 | KMT2A (0.57) | EPHX1KMT2APOLBMEN1ALDH1A1 | |
| SCHEMBL13114604 | 0.74 | ALDH1A1 (0.54) | KMT2APOLBMEN1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018069863-A1 | 1,3 DI-SUBSTITUTED CYCLOBUTANE OR AZETIDINE DERIVATIVES AS HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-04-19 | — | — | WO | disclosed |