Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10379783 | 0.91 | ALDH1A1 (0.46) | ALDH1A1KMT2ASMN1; SMN2L3MBTL1SLC6A3 | |
| SCHEMBL10379312 | 0.85 | GAA (0.51) | ALDH1A1KMT2ASMN1; SMN2L3MBTL1SLC6A3 | |
| SCHEMBL10379541 | 0.84 | GAA (0.52) | ALDH1A1KMT2ASMN1; SMN2L3MBTL1SLC6A3 | |
| SCHEMBL10379362 | 0.81 | EPHX2 (0.40) | L3MBTL1SLC6A3EPHX1GAANPC1 | |
| SCHEMBL10379316 | 0.80 | L3MBTL1 (0.46) | ALDH1A1KMT2ASMN1; SMN2L3MBTL1SLC6A3 | |
| SCHEMBL10378525 | 0.80 | POLB (0.47) | ALDH1A1KMT2ASMN1; SMN2L3MBTL1SLC6A3 | |
| SCHEMBL20063945 | 0.80 | EPHX1 (0.54) | ALDH1A1KMT2AMAPTEPHX1GAA | |
| SCHEMBL9839589 | 0.80 | ALDH1A1 (0.47) | ALDH1A1KMT2ASMN1; SMN2L3MBTL1SLC6A3 | |
| SCHEMBL9839155 | 0.78 | ALDH1A1 (0.46) | ALDH1A1KMT2ASMN1; SMN2L3MBTL1SLC6A3 | |
| SCHEMBL10379521 | 0.78 | GAA (0.54) | ALDH1A1KMT2AL3MBTL1MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0215601-B1 | CYCLOALKYL-SUBSTITUTED 4-AMINOPHENYL DERIVATIVES AND PROCESSFOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.r.l. (IT) | 1990-03-14 | — | — | EP | disclosed |
| US-4769483-A | Cycloalkyl-substituted 4-aminophenyl derivatives and process for their preparation | FARMITALIA CARLO ERBA, S.P.A. (IT) | 1988-09-06 | — | — | US | disclosed |
| EP-0215601-A2 | Cycloalkyl-substituted 4-aminophenyl derivatives and processfor their preparation | FARMITALIA CARLO ERBA S.r.l. (IT) | 1987-03-25 | — | — | EP | disclosed |