Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 12/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.41 |
| ▸ | ACACB | O00763 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 3/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | HRH2 | P25021 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20283137 | 0.83 | CHRM4 (0.41) | HRH4HRH3HRH1KCNH2HRH2 | |
| SCHEMBL12525108 | 0.81 | GPR119 (0.47) | HRH4GPR119KCNH2MAPK1 | |
| SCHEMBL20064080 | 0.80 | HRH3 (0.40) | HRH4HRH3 | |
| SCHEMBL24964199 | 0.79 | HRH4 (0.53) | HRH4HRH3 | |
| SCHEMBL20283121 | 0.79 | CHRM4 (0.47) | HRH4ACACB | |
| SCHEMBL20064397 | 0.79 | ACACB (0.39) | ACACBGPR119KCNH2MAPK1 | |
| SCHEMBL17972943 | 0.78 | TSHR (0.39) | ACACBGPR119KCNH2MAPK1 | |
| SCHEMBL16472351 | 0.78 | ACACB (0.39) | ACACBGPR119KCNH2MAPK1 | |
| SCHEMBL19604915 | 0.77 | HRH3 (0.45) | HRH4HRH3GPR119KCNH2 | |
| SCHEMBL20283122 | 0.76 | ACACB (0.49) | HRH4HRH3ACACBKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018069863-A1 | 1,3 DI-SUBSTITUTED CYCLOBUTANE OR AZETIDINE DERIVATIVES AS HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-04-19 | — | — | WO | disclosed |