Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 8/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28250290 | 0.85 | HRH4 (0.51) | HRH3HRH4 | |
| SCHEMBL20064017 | 0.80 | HRH4 (0.44) | HRH3HRH4 | |
| SCHEMBL725763 | 0.80 | KDM4E (0.51) | KDM4EALDH1A1LMNAHRH4MAPT | |
| SCHEMBL23023324 | 0.79 | LMNA (0.47) | KDM4EALDH1A1LMNAHRH4MAPT | |
| SCHEMBL20283137 | 0.79 | CHRM4 (0.41) | HRH3KDM4EHRH4 | |
| Hydrochloric Acid SCHEMBL8695078 | 0.79 | KDM4E (0.50) | KDM4EALDH1A1LMNAHRH4MAPT | |
| SCHEMBL29969592 | 0.77 | KDM4E (0.49) | HRH3KDM4EALDH1A1HRH4MAPT | |
| SCHEMBL13703141 | 0.76 | ALDH1A1 (0.43) | KDM4EALDH1A1LMNAMAPTCYP2C19 | |
| SCHEMBL20283121 | 0.74 | CHRM4 (0.47) | HRH4 | |
| SCHEMBL24964199 | 0.74 | HRH4 (0.53) | HRH3KDM4EALDH1A1LMNAHRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018069863-A1 | 1,3 DI-SUBSTITUTED CYCLOBUTANE OR AZETIDINE DERIVATIVES AS HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-04-19 | — | — | WO | disclosed |