Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 9/20 | 0.52 |
| ▸ | HPGD | P15428 | 4/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.49 |
| ▸ | USP2 | O75604 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20064101 | 0.82 | ALDH1A1 (0.48) | ALDH1A1HSD17B10HPGDCYP3A4USP2 | |
| SCHEMBL26155106 | 0.76 | OGA (0.35) | ALDH1A1HSD17B10HPGDCYP3A4USP2 | |
| SCHEMBL26049676 | 0.74 | ALDH1A1 (0.57) | ALDH1A1HSD17B10HPGDCYP3A4USP2 | |
| SCHEMBL20064104 | 0.73 | HSD17B10 (0.43) | ALDH1A1HSD17B10HPGDCYP3A4USP2 | |
| SCHEMBL17135754 | 0.73 | HSD17B10 (0.69) | ALDH1A1HSD17B10HPGDCYP3A4USP2 | |
| SCHEMBL16236124 | 0.71 | ALDH1A1 (0.53) | ALDH1A1HSD17B10HPGDCYP3A4USP2 | |
| SCHEMBL14892841 | 0.71 | ALDH1A1 (0.67) | ALDH1A1HSD17B10HPGDCYP3A4USP2 | |
| SCHEMBL6663539 | 0.71 | — | — | |
| SCHEMBL10498542 | 0.71 | LMNA (0.70) | ALDH1A1CYP3A4USP2LMNAKDM4E | |
| Hydrochloric Acid SCHEMBL16236313 | 0.70 | ALDH1A1 (0.56) | ALDH1A1HSD17B10HPGDCYP3A4USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018069863-A1 | 1,3 DI-SUBSTITUTED CYCLOBUTANE OR AZETIDINE DERIVATIVES AS HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-04-19 | — | — | WO | disclosed |