Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 10/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20064103 | 0.73 | ALDH1A1 (0.52) | HSD17B10ALDH1A1HPGDCYP3A4USP2 | |
| SCHEMBL20064101 | 0.70 | ALDH1A1 (0.48) | HSD17B10ALDH1A1HPGDCYP3A4USP2 | |
| SCHEMBL25696791 | 0.69 | HSD17B10 (0.53) | HSD17B10ALDH1A1HPGDCYP3A4USP2 | |
| SCHEMBL21227883 | 0.68 | GPR119 (0.46) | HSD17B10ALDH1A1HPGDCYP3A4USP2 | |
| SCHEMBL17135754 | 0.62 | HSD17B10 (0.69) | HSD17B10ALDH1A1HPGDCYP3A4USP2 | |
| Methanesulfonamide SCHEMBL27786627 | 0.62 | LMNA (0.62) | HSD17B10ALDH1A1HPGDCYP3A4USP2 | |
| SCHEMBL18228600 | 0.61 | KDM4E (0.60) | HSD17B10ALDH1A1CYP3A4USP2CYP2D6 | |
| SCHEMBL2168776 | 0.61 | KDM4E (0.60) | HSD17B10ALDH1A1CYP3A4USP2CYP2D6 | |
| SCHEMBL3339822 | 0.61 | KDM4E (0.60) | HSD17B10ALDH1A1CYP3A4USP2CYP2D6 | |
| SCHEMBL21843786 | 0.61 | LMNA (0.48) | HSD17B10ALDH1A1HPGDCYP3A4USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018069863-A1 | 1,3 DI-SUBSTITUTED CYCLOBUTANE OR AZETIDINE DERIVATIVES AS HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-04-19 | — | — | WO | disclosed |