Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 3/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | MMP1 | P03956 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
| ▸ | MMP12 | P39900 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.30 |
| ▸ | HRH1 | P35367 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20064637 | 0.82 | S1PR5 (0.37) | MCHR1MEN1KMT2APDE4B | |
| SCHEMBL21222449 | 0.78 | ENPP2 (0.34) | ARMEN1KMT2A | |
| SCHEMBL20064111 | 0.78 | ENPP2 (0.34) | ARMEN1KMT2A | |
| SCHEMBL20064626 | 0.74 | ALDH1A1 (0.53) | MEN1KMT2A | |
| SCHEMBL4365529 | 0.71 | PDE4B (0.56) | MEN1KMT2ANPSR1PDE4B | |
| SCHEMBL16333708 | 0.71 | HRH1 (0.41) | MCHR1POLBMEN1KMT2ANPSR1 | |
| SCHEMBL20064615 | 0.70 | PDE4A (0.45) | MCHR1HTR2CHTR2BPDE4BHRH1 | |
| SCHEMBL19510885 | 0.69 | MCHR1 (0.39) | MCHR1HTR2CHTR2BPOLBMEN1 | |
| SCHEMBL7097826 | 0.69 | SLC6A2 (0.45) | MCHR1HTR2CHTR2BPOLBAR | |
| SCHEMBL10605456 | 0.69 | MCHR1 (0.51) | MCHR1MMP1MMP9MMP12PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018069863-A1 | 1,3 DI-SUBSTITUTED CYCLOBUTANE OR AZETIDINE DERIVATIVES AS HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-04-19 | — | — | WO | disclosed |