Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | SCD | O00767 | 3/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.30 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.30 |
| ▸ | KDM1A | O60341 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.30 |
| ▸ | F10 | P00742 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21222419 | 0.89 | HPGD (0.35) | HCRTR2SCDHPGDALDH1A1MAPT | |
| SCHEMBL21222416 | 0.89 | HPGD (0.35) | HCRTR2SCDHPGDALDH1A1MAPT | |
| SCHEMBL21222128 | 0.82 | ALDH1A1 (0.39) | SCDHPGDALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL21222130 | 0.82 | ALDH1A1 (0.39) | SCDHPGDALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL21222019 | 0.81 | CHRM4 (0.34) | SCDHPGDALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL21222017 | 0.81 | CHRM4 (0.34) | SCDHPGDALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL21222336 | 0.79 | HDAC3 (0.32) | ACKR3HDAC6 | |
| SCHEMBL21222339 | 0.79 | HDAC3 (0.32) | ACKR3HDAC6 | |
| SCHEMBL20064062 | 0.76 | PPARA (0.31) | — | |
| SCHEMBL20064413 | 0.76 | GPBAR1 (0.34) | ACKR3GPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018069863-A1 | 1,3 DI-SUBSTITUTED CYCLOBUTANE OR AZETIDINE DERIVATIVES AS HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-04-19 | — | — | WO | disclosed |