Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.49 |
| ▸ | AHR | P35869 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | NPY1R | P25929 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPY2R | P49146 | 1/20 | 0.47 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2003398 | 0.83 | LMNA (0.55) | LMNAALDH1A1SMN1; SMN2MAPTHDAC1 | |
| SCHEMBL4083861 | 0.83 | TUBB4A (0.50) | LMNAALDH1A1SMN1; SMN2MAPTHDAC1 | |
| SCHEMBL2003834 | 0.83 | LMNA (0.55) | LMNAALDH1A1SMN1; SMN2MAPTHDAC1 | |
| SCHEMBL2006480 | 0.82 | LMNA (0.48) | LMNAALDH1A1SMN1; SMN2MAPTHDAC1 | |
| SCHEMBL2002459 | 0.82 | LMNA (0.52) | LMNAALDH1A1SMN1; SMN2MAPTHDAC1 | |
| SCHEMBL2005719 | 0.82 | LMNA (0.52) | LMNAALDH1A1SMN1; SMN2MAPTHDAC1 | |
| SCHEMBL2005437 | 0.81 | LMNA (0.53) | LMNAALDH1A1SMN1; SMN2MAPTHDAC1 | |
| SCHEMBL2004265 | 0.81 | LMNA (0.55) | LMNAALDH1A1SMN1; SMN2MAPTHDAC1 | |
| SCHEMBL2008699 | 0.81 | LMNA (0.52) | LMNAALDH1A1SMN1; SMN2MAPTHDAC1 | |
| SCHEMBL2005389 | 0.81 | LMNA (0.53) | LMNAALDH1A1SMN1; SMN2MAPTHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |