Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | AHR | P35869 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2006648 | 0.83 | LMNA (0.53) | LMNAALDH1A1MAPTSMN1; SMN2AHR | |
| SCHEMBL2010757 | 0.83 | RXFP1 (0.58) | LMNAALDH1A1MAPTSMN1; SMN2AHR | |
| SCHEMBL2001659 | 0.83 | LMNA (0.47) | LMNAALDH1A1MAPTSMN1; SMN2AHR | |
| SCHEMBL2002181 | 0.83 | LMNA (0.52) | LMNAALDH1A1MAPTSMN1; SMN2AHR | |
| SCHEMBL2006378 | 0.82 | LMNA (0.47) | LMNAALDH1A1MAPTSMN1; SMN2AHR | |
| SCHEMBL3001659 | 0.82 | TUBB4A (0.50) | LMNAALDH1A1MAPTSMN1; SMN2AHR | |
| SCHEMBL2005436 | 0.82 | LMNA (0.48) | LMNAALDH1A1MAPTSMN1; SMN2AHR | |
| SCHEMBL2005143 | 0.82 | AHR (0.74) | LMNAALDH1A1MAPTSMN1; SMN2AHR | |
| SCHEMBL2004801 | 0.81 | LMNA (0.47) | LMNAALDH1A1MAPTSMN1; SMN2AHR | |
| SCHEMBL2003315 | 0.81 | LMNA (0.52) | LMNAALDH1A1MAPTSMN1; SMN2AHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |