Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 3/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12319289 | 1.00 | CCR5 (0.38) | CCR5PARP1GPR119HSD17B10 | |
| SCHEMBL18693632 | 1.00 | CCR5 (0.38) | CCR5PARP1GPR119HSD17B10 | |
| SCHEMBL993785 | 1.00 | CCR5 (0.38) | CCR5PARP1GPR119HSD17B10 | |
| SCHEMBL8569713 | 0.89 | HSD17B10 (0.43) | PARP1HSD17B10 | |
| SCHEMBL30181867 | 0.89 | HSD17B10 (0.43) | PARP1HSD17B10 | |
| SCHEMBL1467690 | 0.88 | NR1H2 (0.39) | CCR5PARP1GPR119HSD17B10 | |
| SCHEMBL19549723 | 0.88 | NR1H2 (0.39) | CCR5PARP1GPR119HSD17B10 | |
| SCHEMBL19549724 | 0.88 | NR1H2 (0.39) | CCR5PARP1GPR119HSD17B10 | |
| SCHEMBL16763830 | 0.88 | NR1H2 (0.39) | CCR5PARP1GPR119HSD17B10 | |
| SCHEMBL1135308 | 0.88 | GPR119 (0.39) | CCR5GPR119HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180105522-A1 | N-SULFONYLATED PYRAZOLO[3,4-b]PYRIDIN-6-CARBOXAMIDES AND METHOD OF USE | GALAPAGOS SASU (FR) | 2018-04-19 | — | — | US | disclosed |
| US-20180105522-A1 | N-SULFONYLATED PYRAZOLO[3,4-b]PYRIDIN-6-CARBOXAMIDES AND METHOD OF USE | GALAPAGOS SASU (FR) | 2018-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180105522-A1 | N-SULFONYLATED PYRAZOLO[3,4-b]PYRIDIN-6-CARBOXAMIDES AND METHOD OF USE | CFTR, P2RY1, P2RX5 | CCR5 268/4885PARP1 1967/4885GPR119 231/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.