Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 9/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | GUCY1A1 | Q02108 | 9/20 | 0.47 |
| ▸ | GUCY1B1 | Q02153 | 9/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18212218 | 0.82 | ADORA3 (0.58) | PDE5AADORA3KCNH2GUCY1A1GUCY1B1 | |
| Etriciguat SCHEMBL419874 | 0.81 | ADORA3 (0.56) | PDE5AADORA3KCNH2GUCY1A1GUCY1B1 | |
| Etriciguat SCHEMBL29388720 | 0.81 | ADORA3 (0.56) | PDE5AADORA3KCNH2GUCY1A1GUCY1B1 | |
| SCHEMBL6215423 | 0.81 | ADORA3 (0.53) | PDE5AADORA3KCNH2GUCY1A1GUCY1B1 | |
| SCHEMBL174189 | 0.80 | ADORA3 (0.61) | PDE5AADORA3KCNH2GUCY1A1GUCY1B1 | |
| SCHEMBL174830 | 0.80 | ADORA3 (0.63) | PDE5AADORA3KCNH2GUCY1A1GUCY1B1 | |
| SCHEMBL7835258 | 0.79 | ADORA3 (0.65) | PDE5AADORA3KCNH2GUCY1A1GUCY1B1 | |
| SCHEMBL27557251 | 0.79 | ADORA3 (0.60) | PDE5AADORA3KCNH2GUCY1A1GUCY1B1 | |
| SCHEMBL20682623 | 0.78 | ADORA3 (0.57) | PDE5AADORA3KCNH2GUCY1A1GUCY1B1 | |
| SCHEMBL974087 | 0.77 | ADORA3 (0.56) | PDE5AADORA3KCNH2GUCY1A1GUCY1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018069126-A1 | COMBINATION CONTAINING SGC STIMULATORS AND MINERALOCORTICOID RECEPTOR ANTAGONISTS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-04-19 | — | — | WO | disclosed |