Etriciguat

Etriciguat

SCHEMBL419874

Nc1nc(-c2nn(Cc3ccccc3F)c3ncccc23)ncc1-c1ccncc1

nearest known ligand 0.68

Full drug profile on Sugi Atlas →

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 1/20 0.56
KCNH2 Q12809 1/20 0.56
PDE5A O76074 8/20 0.55
BUB1 O43683 7/20 0.51
GUCY1A1 Q02108 3/20 0.48
GUCY1B1 Q02153 3/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Etriciguat SCHEMBL29388720 1.00 ADORA3 (0.56) ADORA3KCNH2PDE5ABUB1GUCY1A1
SCHEMBL18212218 0.94 ADORA3 (0.58) ADORA3KCNH2PDE5AGUCY1A1GUCY1B1
SCHEMBL6068522 0.93 ADORA3 (0.49) ADORA3KCNH2PDE5ABUB1GUCY1A1
SCHEMBL25688767 0.89 PDE5A (0.57) ADORA3KCNH2PDE5ABUB1
SCHEMBL6068302 0.89 BUB1 (0.47) ADORA3KCNH2PDE5ABUB1GUCY1A1
SCHEMBL6217157 0.87 ADORA3 (0.61) ADORA3KCNH2PDE5AGUCY1A1GUCY1B1
SCHEMBL6068406 0.87 BUB1 (0.48) ADORA3KCNH2PDE5ABUB1GUCY1A1
SCHEMBL6068827 0.86 L3MBTL1 (0.47) ADORA3KCNH2PDE5ABUB1GUCY1A1
SCHEMBL174189 0.86 ADORA3 (0.61) ADORA3KCNH2PDE5AGUCY1A1GUCY1B1
SCHEMBL16594600 0.86 ADORA3 (0.57) ADORA3KCNH2PDE5AGUCY1A1GUCY1B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 202 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3498298-A1 THE USE OF SGC STIMULATORS AND SGC ACTIVATORS ALONE OR IN COMBINATION WITH PDE5 INHIBITORS FOR THE TREATMENT OF BONE DISORDERS INCLUDING OSTEOGENESIS IMPERFECTA (OI) Bayer AG (DE) 2019-06-19 EP claimed
US-20180169095-A1 THE USE OF SGC STIMULATORS, SGC ACTIVATORS, ALONE AND COMBINATIONS WITH PDE5 INHIBITORS FOR THE TREATMENT OF DIGITAL ULCERS (DU) CONCOMITANT TO SYSTEMIC SCLEROSIS (SSC) BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2018-06-21 US claimed
EP-3291811-A1 THE USE OF SGC STIMULATORS, SGC ACTIVATORS, ALONE AND COMBINATIONS WITH PDE5 INHIBITORS FOR THE TREATMENT OF DIGITAL ULCERS (DU) CONCOMITANT TO SYSTEMIC SCLEROSIS (SSC) Bayer Pharma Aktiengesellschaft (DE) 2018-03-14 EP claimed
WO-2016177660-A1 THE USE OF SGC STIMULATORS, SGC ACTIVATORS, ALONE AND COMBINATIONS WITH PDE5 INHIBITORS FOR THE TREATMENT OF DIGITAL ULCERS (DU) CONCOMITANT TO SYSTEMIC SCLEROSIS (SSC) BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2016-11-10 WO claimed
US-20160158233-A1 SGC STIMULATORS OR SGC ACTIVATORS AND PDE5 INHIBITORS IN COMBINATION WITH ADDITIONAL TREATMENT FOR THE THERAPY OF CYSTIC FIBROSIS BAYER PHARMA AKTIENGESELl SCHAFT (DE) 2016-06-09 US claimed
EP-2531187-B1 sGC STIMULATORS OR sGC ACTIVATORS ALONE AND IN COMBINATION WITH PDE5 INHBITORS FOR THE TREATMENT OF CYSTIC FIBROSIS ADVERIO PHARMA GMBH (DE) 2015-08-12 EP claimed
US-20130035340-A1 sGC STIMULATORS OR sGC ACTIVATORS ALONE AND IN COMBINATION WITH PDE5 INHBITORS FOR THE TREATMENT OF CYSTIC FIBROSIS BAYER INTELLECTUAL PROPERTY GMBH (DE) 2013-02-07 US claimed
EP-2531187-A1 sGC STIMULATORS OR sGC ACTIVATORS ALONE AND IN COMBINATION WITH PDE5 INHBITORS FOR THE TREATMENT OF CYSTIC FIBROSIS Bayer Intellectual Property GmbH (DE) 2012-12-12 EP claimed
US-20120022028-A1 SGC STIMULATORS OR SGC ACTIVATORS IN COMBINATION WITH PDE5 INHIBITORS FOR THE TREATMENT OF ERECTILE DYSFUNCTION BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2012-01-26 US claimed
EP-2387404-A2 SGC STIMULATORS OF SGC ACTIVATORS IN COMBINATION WITH PDE5 INHBITORS FOR THE TREATMENT OF ERECTILE DYSFUNCTION Bayer Pharma Aktiengesellschaft (DE) 2011-11-23 EP claimed
WO-2011095534-A1 sGC STIMULATORS OR sGC ACTIVATORS ALONE AND IN COMBINATION WITH PDE5 INHBITORS FOR THE TREATMENT OF CYSTIC FIBROSIS BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2011-08-11 WO claimed
US-20110092500-A1 SGC STIMULATORS, SGC ACTIVATORS AND COMBINATIONS THEREOF FOR THE TREATMENT OF HEARING IMPAIRMENT BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2011-04-21 US claimed
EP-2296661-A1 SGC STIMULATORS, SGC ACTIVATORS AND COMBINATIONS THEREOF FOR THE TREATMENT OF HEARING IMPAIRMENT Bayer Schering Pharma Aktiengesellschaft (DE) 2011-03-23 EP claimed
US-20100210643-A1 sGC STIMULATORS, sGC ACTIVATORS AND COMBINATIONS FOR THE TREATMENT OF UROLOGICAL DISORDERS BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2010-08-19 US claimed
WO-2010081647-A2 SGC STIMULATORS OF SGC ACTIVATORS IN COMBINATION WITH PDE5 INHBITORS FOR THE TREATMENT OF ERECTILE DYSFUNCTION BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2010-07-22 WO claimed
EP-2144605-A1 sGC STIMULATORS, sGC ACTIVATORS AND COMBINATIONS FOR THE TREATMENT OF UROLOGICAL DISORDERS Bayer HealthCare AG (DE) 2010-01-20 EP claimed
WO-2009138165-A1 SGC STIMULATORS, SGC ACTIVATORS AND COMBINATIONS THEREOF FOR THE TREATMENT OF HEARING IMPAIRMENT BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2009-11-19 WO claimed
WO-2008138483-A1 sGC STIMULATORS, sGC ACTIVATORS AND COMBINATIONS FOR THE TREATMENT OF UROLOGICAL DISORDERS BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2008-11-20 WO claimed
EP-1499369-A1 STENTS CONTAINING PYRIDINE-SUBSTITUTED PYRAZOLOPYRIDINE DERIVATIVES Bayer Aktiengesellschaft (DE) 2005-01-26 EP claimed
WO-2003089024-A1 STENTS CONTAINING PYRIDINE-SUBSTITUTED PYRAZOLOPYRIDINE DERIVATIVES BAYER HEALTHCARE AG (DE) 2003-10-30 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130035340-A1 sGC STIMULATORS OR sGC ACTIVATORS ALONE AND IN COMBINATION WITH PDE5 INHBITORS FOR THE TREATMENT OF CYSTIC FIBROSIS PDE5A, PDE3B, PDE3A ADORA3 1626/4885KCNH2 1362/4885PDE5A 1/4885
US-20180169095-A1 THE USE OF SGC STIMULATORS, SGC ACTIVATORS, ALONE AND COMBINATIONS WITH PDE5 INHIBITORS FOR THE TREATMENT OF DIGITAL ULCERS (DU) CONCOMITANT TO SYSTEMIC SCLEROSIS (SSC) PDE5A, PDE2A, PDE3A ADORA3 3072/4885KCNH2 2945/4885PDE5A 1/4885
US-20110092500-A1 SGC STIMULATORS, SGC ACTIVATORS AND COMBINATIONS THEREOF FOR THE TREATMENT OF HEARING IMPAIRMENT GUCY1A2, GUCY1A1, GUCY1B1 ADORA3 301/4885KCNH2 897/4885PDE5A 10/4885
US-20160158233-A1 SGC STIMULATORS OR SGC ACTIVATORS AND PDE5 INHIBITORS IN COMBINATION WITH ADDITIONAL TREATMENT FOR THE THERAPY OF CYSTIC FIBROSIS PDE5A, PDE3A, GMPS ADORA3 1527/4885KCNH2 1661/4885PDE5A 1/4885
US-20100210643-A1 sGC STIMULATORS, sGC ACTIVATORS AND COMBINATIONS FOR THE TREATMENT OF UROLOGICAL DISORDERS PDE5A, PDE3B, PDE3A ADORA3 2112/4885KCNH2 2632/4885PDE5A 1/4885
US-20120022028-A1 SGC STIMULATORS OR SGC ACTIVATORS IN COMBINATION WITH PDE5 INHIBITORS FOR THE TREATMENT OF ERECTILE DYSFUNCTION PDE5A, PDE3A, PDE3B ADORA3 1516/4885KCNH2 2274/4885PDE5A 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.