Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SORT1 | Q99523 | 4/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | PIK3C3 | Q8NEB9 | 5/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.46 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | PRNP | P04156 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5632488 | 0.81 | CYP1A2 (0.53) | CYP1A2KDM4ELMNAL3MBTL1PIK3C3 | |
| SCHEMBL4543263 | 0.81 | CYP1A2 (0.56) | CYP1A2KDM4ELMNAL3MBTL1PIK3C3 | |
| SCHEMBL14667358 | 0.80 | CYP1A2 (0.56) | SORT1CYP1A2RIPK1KDM4ELMNA | |
| SCHEMBL18900166 | 0.80 | SORT1 (0.50) | SORT1RIPK1LMNAPIK3C3GRM5 | |
| SCHEMBL29013232 | 0.79 | CYP1A2 (0.51) | SORT1CYP1A2KDM4ELMNAL3MBTL1 | |
| SCHEMBL30311946 | 0.79 | CYP1A2 (0.51) | SORT1CYP1A2KDM4ELMNAL3MBTL1 | |
| SCHEMBL15305788 | 0.79 | HRH4 (0.52) | CYP1A2KDM4ELMNAL3MBTL1MAPK8 | |
| SCHEMBL17541672 | 0.79 | PTK2 (0.51) | SORT1CYP1A2KDM4ELMNAL3MBTL1 | |
| SCHEMBL1428795 | 0.79 | SORT1 (0.52) | SORT1RIPK1KDM4ELMNAGRM5 | |
| SCHEMBL24714802 | 0.77 | CYP1A2 (0.49) | CYP1A2KDM4ELMNAL3MBTL1PIK3C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3194383-B1 | QUINOLINONE PYRIMIDINES COMPOSITIONS AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS | FORMA THERAPEUTICS INC (US) | 2019-11-06 | — | — | EP | disclosed |
| WO-2018069468-A1 | BENZOTHIAZOLE DERIVATIVES AS DYRK1 INHIBITORS | PHARMASUM THERAPEUTICS AS (NO) | 2018-04-19 | — | — | WO | disclosed |