Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 11/20 | 0.33 |
| ▸ | HCN1 | O60741 | 1/20 | 0.33 |
| ▸ | HCN4 | Q9Y3Q4 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 2/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.30 |
| ▸ | MMP9 | P14780 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20148058 | 0.87 | MMP1 (0.32) | HRH3MMP13MMP1MMP9 | |
| SCHEMBL20069014 | 0.82 | RET (0.36) | HRH3HCN1HCN4MMP13MMP2 | |
| SCHEMBL20158550 | 0.81 | RET (0.42) | HRH3HCN1HCN4 | |
| SCHEMBL20069707 | 0.80 | RET (0.38) | HRH3HCN1HCN4MMP13MMP2 | |
| SCHEMBL20147532 | 0.74 | MMP9 (0.35) | HRH3MMP13MMP2MMP1MMP9 | |
| SCHEMBL20147531 | 0.73 | MMP9 (0.34) | HRH3MMP13MMP2MMP1MMP9 | |
| SCHEMBL20070401 | 0.73 | CYP2D6 (0.34) | HRH3MMP13MMP2MMP1MMP9 | |
| SCHEMBL20147357 | 0.72 | KDM4E (0.48) | HRH3ALDH1A1 | |
| SCHEMBL20148062 | 0.72 | RET (0.41) | — | |
| SCHEMBL16304087 | 0.72 | DRD2 (0.37) | HRH3MMP13MMP2MMP1MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071454-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |