Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WNT1 | P04628 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 14/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 10/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 8/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | SSTR4 | P31391 | 2/20 | 0.32 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20069434 | 0.77 | CCR2 (0.37) | WNT1GSK3BDYRK1ARET | |
| SCHEMBL21651950 | 0.77 | RET (0.56) | WNT1GSK3BDYRK1ASLC6A2SLC6A4 | |
| SCHEMBL20147339 | 0.74 | WNT1 (0.37) | WNT1GSK3BDYRK1ASLC6A2SLC6A4 | |
| SCHEMBL2911480 | 0.72 | WNT1 (0.41) | WNT1GSK3BDYRK1ASLC6A2SLC6A4 | |
| SCHEMBL25043759 | 0.70 | WNT1 (0.40) | WNT1GSK3BDYRK1ASLC6A2SLC6A4 | |
| SCHEMBL1655323 | 0.70 | ADRA2C (0.42) | WNT1GSK3BDYRK1ASLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL15550523 | 0.68 | ADRA2C (0.41) | WNT1GSK3BDYRK1ASLC6A2SLC6A4 | |
| SCHEMBL2442395 | 0.67 | ADRA2C (0.39) | WNT1GSK3BDYRK1ASLC6A2SLC6A4 | |
| SCHEMBL2881934 | 0.67 | SLC6A2 (0.36) | WNT1GSK3BDYRK1ASLC6A2SLC6A4 | |
| SCHEMBL6519388 | 0.67 | ADRA2C (0.39) | WNT1GSK3BDYRK1ASLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071454-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |