Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | CTSS | P25774 | 2/20 | 0.43 |
| ▸ | CTSK | P43235 | 2/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.42 |
| ▸ | NPFFR1 | Q9GZQ6 | 1/20 | 0.42 |
| ▸ | NPFFR2 | Q9Y5X5 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SCN1A | P35498 | 1/20 | 0.38 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.38 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.38 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20147409 | 0.86 | RET (0.44) | ADRB2ALDH1A1HTTRETCTSS | |
| SCHEMBL20069608 | 0.85 | ADRB2 (0.49) | ADRB2ALDH1A1HTTRETCTSS | |
| SCHEMBL20069533 | 0.83 | ADRB2 (0.47) | ADRB2ALDH1A1HTTRETCTSS | |
| SCHEMBL20069529 | 0.82 | ALDH1A1 (0.45) | ADRB2ALDH1A1HTTRETCTSS | |
| SCHEMBL20069601 | 0.81 | DPP4 (0.49) | ADRB2ALDH1A1HTTRETCTSS | |
| SCHEMBL20069536 | 0.81 | RET (0.47) | ADRB2ALDH1A1HTTRETCTSS | |
| SCHEMBL25502319 | 0.79 | DPP4 (0.50) | ADRB2ALDH1A1HTTRETCTSS | |
| SCHEMBL20069599 | 0.78 | RET (0.45) | ADRB2ALDH1A1HTTRETCTSS | |
| SCHEMBL20069597 | 0.76 | RET (0.46) | ADRB2ALDH1A1HTTRETCTSS | |
| SCHEMBL20205889 | 0.75 | RET (0.47) | ADRB2ALDH1A1HTTRETCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071454-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |