Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 2/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | PLAT | P00750 | 1/20 | 0.37 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | NPFFR1 | Q9GZQ6 | 1/20 | 0.37 |
| ▸ | NPFFR2 | Q9Y5X5 | 1/20 | 0.37 |
| ▸ | XIAP | P98170 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CTRB1 | P17538 | 3/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20205889 | 0.84 | RET (0.47) | RETADRB2ALDH1A1HTTDPP4 | |
| SCHEMBL20147390 | 0.83 | RET (0.46) | RETADRB2ALDH1A1HTTDPP4 | |
| SCHEMBL22856990 | 0.81 | RET (0.45) | RETADRB2ALDH1A1HTTDPP4 | |
| SCHEMBL8125084 | 0.80 | ALDH1A1 (0.46) | ADRB2ALDH1A1HTTPLATSLC6A2 | |
| SCHEMBL7972011 | 0.80 | SLC6A2 (0.37) | RETADRB2ALDH1A1HTTDPP4 | |
| SCHEMBL7904502 | 0.77 | ADRB2 (0.48) | ADRB2ALDH1A1HTTDPP4NPC1 | |
| SCHEMBL20068812 | 0.76 | RET (0.48) | RETADRB2ALDH1A1HTTDPP4 | |
| SCHEMBL20069605 | 0.76 | ADRB2 (0.44) | RETADRB2ALDH1A1HTTDPP4 | |
| SCHEMBL20147399 | 0.75 | RET (0.47) | RETADRB2ALDH1A1HTTDPP4 | |
| SCHEMBL20205887 | 0.75 | RET (0.47) | RETADRB2ALDH1A1HTTDPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071454-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |