Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 5/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 5/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 3/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.41 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.41 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.41 |
| ▸ | NAAA | Q02083 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20069899 | 1.00 | CYP11B1 (0.43) | CYP11B1TRPV6CHRNB2CHRNA4CHRNB4 | |
| Trifluoroacetic Acid SCHEMBL20136779 | 0.88 | CACNA1G (0.44) | CYP11B1TRPV6CHRNB2CHRNA4RET | |
| SCHEMBL22666989 | 0.84 | CHRNB2 (0.46) | CYP11B1TRPV6CHRNB2CHRNA4CHRNB4 | |
| SCHEMBL20153149 | 0.83 | RET (0.46) | CYP11B1TRPV6CHRNB2CHRNA4CHRNB4 | |
| SCHEMBL24624328 | 0.82 | TRPV6 (0.43) | CYP11B1TRPV6CHRNB2CHRNA4CHRNB4 | |
| SCHEMBL22796161 | 0.82 | TRPV6 (0.43) | CYP11B1TRPV6CHRNB2CHRNA4CHRNB4 | |
| SCHEMBL25220183 | 0.81 | TRPV6 (0.42) | CYP11B1TRPV6CHRNB2CHRNA4CHRNB4 | |
| Hydrochloric Acid SCHEMBL29597371 | 0.81 | TRPV6 (0.42) | CYP11B1TRPV6CHRNB2CHRNA4CHRNB4 | |
| SCHEMBL22030910 | 0.81 | CHRNB2 (0.43) | CYP11B1TRPV6CHRNB2CHRNA4CHRNB4 | |
| Hydrochloric Acid SCHEMBL25216416 | 0.80 | TRPV6 (0.42) | CYP11B1TRPV6CHRNB2CHRNA4CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3753939-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | Array Biopharma Inc. (US) | 2020-12-23 | — | — | EP | disclosed |
| EP-3523301-B1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2020-05-27 | — | — | EP | disclosed |
| WO-2018071447-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |