Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
| ▸ | MMP8 | P22894 | 1/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22256382 | 0.70 | CYP2D6 (0.42) | CYP2D6CYP2C19MMP1MMP8EPHX1 | |
| SCHEMBL25795085 | 0.69 | CYP2D6 (0.34) | CYP2D6CYP2C19MMP1MMP8EPHX1 | |
| SCHEMBL24383368 | 0.69 | MLYCD (0.42) | CYP2D6CYP2C19MMP1MMP8EPHX1 | |
| SCHEMBL20883264 | 0.68 | EPHX1 (0.44) | EPHX1CNR1CNR2 | |
| SCHEMBL22606070 | 0.66 | CYP2D6 (0.31) | CYP2D6CYP2C19 | |
| SCHEMBL20804086 | 0.65 | ALDH1A1 (0.35) | — | |
| SCHEMBL28675175 | 0.65 | — | — | |
| SCHEMBL18599853 | 0.65 | — | — | |
| SCHEMBL18625376 | 0.64 | CYP2D6 (0.41) | CYP2D6CYP2C19MMP1MMP8EPHX1 | |
| SCHEMBL24092196 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071454-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |