Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.34 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20071359 | 0.88 | ACACB (0.37) | LMNARET | |
| SCHEMBL20148618 | 0.88 | ALDH1A1 (0.40) | DPP4DPP8DPP7RET | |
| SCHEMBL20148611 | 0.80 | RET (0.37) | ALOX5DPP4DPP8DPP7RET | |
| SCHEMBL18704996 | 0.74 | CHRM1 (0.49) | LMNAGAA | |
| SCHEMBL20148599 | 0.73 | CHRNB2 (0.41) | — | |
| SCHEMBL22030859 | 0.73 | RET (0.43) | DPP4DPP8DPP7TSHRRET | |
| SCHEMBL20148612 | 0.71 | RET (0.42) | KEAP1NFE2L2GAARET | |
| SCHEMBL20148617 | 0.71 | RET (0.42) | DPP4DPP8DPP7RET | |
| SCHEMBL21158897 | 0.70 | RET (0.40) | DPP4DPP8DPP7RET | |
| SCHEMBL20148707 | 0.70 | TDP1 (0.44) | RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071447-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |