Sugi Predict

Sugi Predict / Compounds / SCHEMBL20148707

SCHEMBL20148707

SCHEMBL20148707

Cc1ccc(C(=O)N2C3CC2CN(C(C)C)C3)nc1

nearest known ligand 0.44

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ TDP1 Q9NUW8 1/20 0.44
▸ PDE10A Q9Y233 1/20 0.41
▸ RET P07949 1/20 0.40
▸ HRH3 Q9Y5N1 5/20 0.38
▸ KDM5A P29375 1/20 0.36
▸ HTR1A P08908 2/20 0.35
▸ CSF1R P07333 1/20 0.35
▸ XIAP P98170 1/20 0.35
▸ BIRC2 Q13490 1/20 0.35
▸ GRIN2B Q13224 1/20 0.33
▸ OPRM1 P35372 1/20 0.32
▸ OPRD1 P41143 1/20 0.32
▸ OPRK1 P41145 1/20 0.32
▸ L3MBTL3 Q96JM7 1/20 0.32
▸ L3MBTL1 Q9Y468 1/20 0.32
▸ MAPT P10636 1/20 0.32
▸ RAB9A P51151 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20069581 0.85 TDP1 (0.44) TDP1PDE10ARETKDM5AHTR1A
SCHEMBL20148714 0.81 PDE10A (0.43) PDE10ARETCSF1ROPRM1
SCHEMBL20148709 0.80 L3MBTL1 (0.48) PDE10ARETL3MBTL1
SCHEMBL20148708 0.79 PDE10A (0.42) PDE10ARETKDM5ACSF1RMAPT
SCHEMBL18705129 0.79 HTR1A (0.38) TDP1RETHRH3HTR1AOPRM1
SCHEMBL20148697 0.77 SIRT6 (0.44) RETHRH3OPRM1
SCHEMBL20148711 0.76 HDAC1 (0.40) PDE10ARETHRH3
SCHEMBL20069574 0.75 NNMT (0.43) RETHRH3OPRM1
SCHEMBL20148715 0.74 HCAR2 (0.43) RETCSF1R
SCHEMBL20148701 0.74 HRH3 (0.38) RETHRH3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240066029-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA INC. 2024-02-29 — — US disclosed
US-20180133200-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA INC. 2018-05-17 — — US disclosed
US-20180133213-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA INC. 2018-05-17 — — US disclosed
US-20180134702-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA INC. 2018-05-17 — — US disclosed
US-20180134702-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA INC. 2018-05-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180134702-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS RET, ROR1, BRAF TDP1 1003/4885PDE10A 822/4885RET 1/4885
US-20180133200-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS RET, ROR1, BRAF TDP1 1003/4885PDE10A 822/4885RET 1/4885
US-20180133213-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS RET, ROR1, BRAF TDP1 1003/4885PDE10A 822/4885RET 1/4885
US-20240066029-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS RET, ROR1, BRAF TDP1 1003/4885PDE10A 822/4885RET 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.