Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ACACB | O00763 | 1/20 | 0.41 |
| ▸ | ACACA | Q13085 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.39 |
| ▸ | TACR1 | P25103 | 3/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20066070 | 0.84 | CYP2D6 (0.46) | OPRM1OPRD1OPRK1OPRL1LMNA | |
| SCHEMBL24609048 | 0.80 | MEN1 (0.49) | LMNAKDM4EPOLBKMT2AALDH1A1 | |
| SCHEMBL23778367 | 0.79 | CYP2D6 (0.52) | OPRM1OPRD1OPRK1OPRL1LMNA | |
| SCHEMBL23778311 | 0.79 | CYP2D6 (0.52) | OPRM1OPRD1OPRK1OPRL1LMNA | |
| SCHEMBL20073973 | 0.78 | POLB (0.48) | LMNAKDM4EPOLBMAPTKMT2A | |
| SCHEMBL20066072 | 0.77 | OPRM1 (0.44) | OPRM1OPRD1OPRK1OPRL1KDM4E | |
| SCHEMBL29709409 | 0.77 | OPRM1 (0.44) | OPRM1OPRD1OPRK1OPRL1KDM4E | |
| SCHEMBL20073800 | 0.76 | PDE10A (0.39) | OPRM1OPRL1LMNAPOLBPKM | |
| SCHEMBL20073809 | 0.76 | PDE10A (0.39) | OPRM1OPRL1LMNAPOLBPKM | |
| SCHEMBL4562996 | 0.73 | OPRL1 (0.60) | OPRM1OPRK1OPRL1KDM4EKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018069732-A1 | HETEROCYCLIC COMPOUNDS HAVING ACTIVITY AS MODULATORS OF MUSCARINIC M1 AND/OR M4 RECEPTORS IN THE TREATMENT OF CNS DISEASES AND PAINS. | HEPTARES THERAPEUTICS LIMITED (GB) | 2018-04-19 | — | — | WO | disclosed |