Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.38 |
| ▸ | TACR1 | P25103 | 2/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.38 |
| ▸ | CCR5 | P51681 | 2/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20073800 | 1.00 | PDE10A (0.39) | PDE10APOLBPKMLMNAMAPT | |
| SCHEMBL20066002 | 0.83 | CYP2D6 (0.50) | PDE10APOLBPKMLMNAMAPT | |
| SCHEMBL20066001 | 0.83 | CYP2D6 (0.50) | PDE10APOLBPKMLMNAMAPT | |
| SCHEMBL20066069 | 0.77 | CYP2D6 (0.47) | POLBPKMLMNAMAPTOPRL1 | |
| SCHEMBL24609048 | 0.76 | MEN1 (0.49) | POLBLMNAALDH1A1KMT2ACHRM4 | |
| SCHEMBL20066003 | 0.76 | OPRM1 (0.41) | PDE10AOPRL1KCNH2OPRM1HRH3 | |
| SCHEMBL20066004 | 0.76 | OPRM1 (0.41) | PDE10AOPRL1KCNH2OPRM1HRH3 | |
| SCHEMBL20073700 | 0.76 | OPRM1 (0.42) | POLBPKMLMNAMAPTOPRL1 | |
| SCHEMBL20073973 | 0.75 | POLB (0.48) | POLBLMNAMAPTALDH1A1KMT2A | |
| SCHEMBL21120345 | 0.72 | PDE10A (0.39) | PDE10ACHRM4KCNH2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018069732-A1 | HETEROCYCLIC COMPOUNDS HAVING ACTIVITY AS MODULATORS OF MUSCARINIC M1 AND/OR M4 RECEPTORS IN THE TREATMENT OF CNS DISEASES AND PAINS. | HEPTARES THERAPEUTICS LIMITED (GB) | 2018-04-19 | — | — | WO | disclosed |