Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | AHR | P35869 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.42 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.42 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2005436 | 0.91 | LMNA (0.48) | LMNAALDH1A1AHRMAPTSMN1; SMN2 | |
| SCHEMBL2012914 | 0.91 | LMNA (0.56) | LMNAALDH1A1AHRMAPTSMN1; SMN2 | |
| SCHEMBL2002885 | 0.90 | LMNA (0.47) | LMNAALDH1A1AHRMAPTSMN1; SMN2 | |
| SCHEMBL2002890 | 0.88 | AHR (0.49) | LMNAALDH1A1AHRMAPTSMN1; SMN2 | |
| SCHEMBL2002871 | 0.86 | LMNA (0.53) | LMNAALDH1A1AHRMAPTSMN1; SMN2 | |
| SCHEMBL1999240 | 0.85 | IRAK4 (0.51) | LMNAALDH1A1AHRMAPTSMN1; SMN2 | |
| SCHEMBL2002672 | 0.85 | LMNA (0.48) | LMNAALDH1A1AHRMAPTSMN1; SMN2 | |
| SCHEMBL2006000 | 0.85 | LMNA (0.48) | LMNAALDH1A1AHRMAPTSMN1; SMN2 | |
| SCHEMBL2000164 | 0.84 | AHR (0.50) | LMNAALDH1A1AHRMAPTSMN1; SMN2 | |
| SCHEMBL2007180 | 0.83 | PLA2G2A (0.50) | LMNAALDH1A1MAPTHSD17B1HSD17B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |