Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.39 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.38 |
| ▸ | YTHDF2 | Q9Y5A9 | 2/20 | 0.38 |
| ▸ | CSF1R | P07333 | 2/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.32 |
| ▸ | YTHDF3 | Q7Z739 | 1/20 | 0.32 |
| ▸ | YTHDF1 | Q9BYJ9 | 1/20 | 0.32 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.32 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.32 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.32 |
| ▸ | PLAT | P00750 | 1/20 | 0.31 |
| ▸ | CASP3 | P42574 | 1/20 | 0.31 |
| ▸ | CDK9 | P50750 | 1/20 | 0.31 |
| ▸ | CASP7 | P55210 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20075889 | 0.76 | PIK3C3 (0.39) | DAOKDM5BPIK3C3YTHDF2CSF1R | |
| SCHEMBL12952998 | 0.69 | PIK3C3 (0.38) | DAOKDM5BPIK3C3YTHDF2PIK3CB | |
| SCHEMBL15083750 | 0.67 | TSHR (0.43) | CSF1RTSHRPOLBTP53TDP1 | |
| SCHEMBL31677037 | 0.65 | CNR2 (0.47) | KDM5B | |
| SCHEMBL2457070 | 0.65 | CCR2 (0.44) | PIK3CBPDE1BPLAT | |
| SCHEMBL20074180 | 0.64 | TSHR (0.45) | DAOKDM5BCSF1RTSHRPOLB | |
| SCHEMBL25037191 | 0.64 | YTHDF2 (0.44) | DAOKDM5BYTHDF2POLBYTHDF3 | |
| SCHEMBL20075888 | 0.62 | YTHDF2 (0.42) | DAOKDM5BYTHDF2POLBPLAT | |
| SCHEMBL20075893 | 0.62 | YTHDF2 (0.42) | DAOKDM5BYTHDF2YTHDF3YTHDF1 | |
| SCHEMBL31499730 | 0.62 | YTHDF2 (0.39) | DAOKDM5BYTHDF2YTHDF3YTHDF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10975084-B2 | KDM5 inhibitors | MERCK SHARP & DOHME CORP. (US) | 2021-04-13 | — | — | US | disclosed |
| US-20200048258-A1 | KDM5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2020-02-13 | — | — | US | disclosed |
| WO-2018071283-A1 | KDM5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2018-04-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200048258-A1 | KDM5 INHIBITORS | KDM5A, KDM5B, KDM5C | DAO 3196/4885KDM5B 2/4885PIK3C3 2173/4885 |
| US-10975084-B2 | KDM5 inhibitors | KDM5A, KDM5B, KDM5C | DAO 3196/4885KDM5B 2/4885PIK3C3 2173/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.