Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.39 |
| ▸ | DAO | P14920 | 1/20 | 0.39 |
| ▸ | YTHDF2 | Q9Y5A9 | 1/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.36 |
| ▸ | TDP2 | O95551 | 1/20 | 0.34 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | PLAT | P00750 | 2/20 | 0.32 |
| ▸ | PDE2A | O00408 | 6/20 | 0.32 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20076035 | 0.90 | YTHDF2 (0.47) | DAOYTHDF2KDM5BPLATNPY5R | |
| SCHEMBL20075893 | 0.88 | YTHDF2 (0.42) | DAOYTHDF2KDM5BPLATNPY5R | |
| SCHEMBL20075888 | 0.88 | YTHDF2 (0.42) | DAOYTHDF2KDM5BPLATNPY5R | |
| SCHEMBL20075886 | 0.86 | NPY5R (0.42) | DAOYTHDF2CSF1RPLATNPY5R | |
| SCHEMBL20074192 | 0.76 | DAO (0.41) | PIK3C3DAOYTHDF2KDM5BPIK3CB | |
| SCHEMBL25037191 | 0.73 | YTHDF2 (0.44) | DAOYTHDF2KDM5BPLAT | |
| SCHEMBL20588719 | 0.72 | KDM4E (0.44) | — | |
| SCHEMBL31499730 | 0.71 | YTHDF2 (0.39) | DAOYTHDF2KDM5BPLATNPY5R | |
| SCHEMBL20075890 | 0.70 | NPY5R (0.38) | DAOKDM5BNPY5R | |
| SCHEMBL20076014 | 0.70 | ALDH1A1 (0.47) | DAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200048259-A1 | KDM5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2020-02-13 | — | — | US | claimed |
| US-20200048259-A1 | KDM5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2020-02-13 | — | — | US | disclosed |
| US-20200048259-A1 | KDM5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2020-02-13 | — | — | US | disclosed |
| WO-2018071282-A1 | KDM5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2018-04-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200048259-A1 | KDM5 INHIBITORS | KDM5A, KDM5B, KDM5C | PIK3C3 2093/4885DAO 3300/4885YTHDF2 656/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.