Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 2/20 | 0.39 |
| ▸ | PPARA | Q07869 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31646318 | 0.83 | CYP1A2 (0.46) | MTNR1AMTNR1BCYP2C19CYP1A2GAA | |
| SCHEMBL11884465 | 0.78 | PARP10 (0.45) | PARP10POLBCTNNB1MTNR1AMTNR1B | |
| SCHEMBL216782 | 0.77 | PARP10 (0.44) | PARP10POLBCTNNB1MTNR1AMTNR1B | |
| SCHEMBL5214433 | 0.77 | PARP10 (0.44) | PARP10POLBCTNNB1MTNR1AMTNR1B | |
| SCHEMBL7101191 | 0.76 | SMN1; SMN2 (0.45) | PARP10MAPTRECQLHSD17B10TDP1 | |
| SCHEMBL7408531 | 0.75 | PARP10 (0.42) | PARP10POLBCTNNB1MTNR1AMTNR1B | |
| SCHEMBL4580738 | 0.75 | PARP10 (0.42) | PARP10POLBCTNNB1MTNR1AMTNR1B | |
| SCHEMBL28319983 | 0.75 | PARP10 (0.42) | PARP10POLBCTNNB1MTNR1AMTNR1B | |
| SCHEMBL995776 | 0.75 | LDHA (0.52) | PARP10POLBCTNNB1MTNR1AMTNR1B | |
| SCHEMBL1328578 | 0.75 | GAA (0.56) | PARP10POLBMTNR1AMTNR1BMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9040707-B2 | Bicyclic thiazoles as allosteric modulators of mGluR5 receptors | JANSSEN PHARMACEUTICA NV (BE) | 2015-05-26 | — | — | US | disclosed |
| EP-2513117-B1 | BICYCLIC THIAZOLES AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS | JANSSEN PHARMACEUTICA NV (BE) | 2013-08-28 | — | — | EP | disclosed |
| EP-2513117-A1 | BICYCLIC THIAZOLES AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS | Janssen Pharmaceutica, N.V. (BE) | 2012-10-24 | — | — | EP | disclosed |
| US-20120258955-A1 | BICYCLIC THIAZOLES AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS | JANSSEN PHARMACEUTICA NV (BE) | 2012-10-11 | — | — | US | disclosed |
| CN-102666552-A | Bicyclic thiazoles as allosteric modulators of the MGLUR5 receptor | JANSSEN PHARMACEUTICA NV | 2012-09-12 | — | — | CN | disclosed |
| WO-2011073339-A1 | BICYCLIC THIAZOLES AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS | JANSSEN PHARMACEUTICA NV (BE) | 2011-06-23 | — | — | WO | disclosed |
| EP-1230230-B1 | INDENO-DIHYDROTHIAZOLE DERIVATIVES, THE PRODUCTION THEREOF AND THEIR USE AS ANORECTIC MEDICAMENTS | AVENTIS PHARMA GMBH (DE) | 2003-09-17 | — | — | EP | disclosed |
| EP-1230230-A1 | INDENO-, NAPHTHO-, AND BENZOCYCLOHEPTA-DIHYDROTHIAZOLE DERIVATIVES, THE PRODUCTION THEREOF AND THEIR USE AS ANORECTIC MEDICAMENTS | Aventis Pharma Deutschland GmbH (DE) | 2002-08-14 | — | — | EP | disclosed |
| US-6387935-B1 | ANOREXIGENIC AGENT | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-05-14 | — | — | US | disclosed |
| WO-2001032638-A1 | INDENO-, NAPHTHO-, AND BENZOCYCLOHEPTA-DIHYDROTHIAZOLE DERIVATIVES, THE PRODUCTION THEREOF AND THEIR USE AS ANORECTIC MEDICAMENTS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2001-05-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120258955-A1 | BICYCLIC THIAZOLES AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS | GRM5, GRIK5, GRM2 | PARP10 4400/4885POLB 4673/4885CTNNB1 4740/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.