Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | PPARA | Q07869 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4368354 | 0.82 | CYP1A2 (0.47) | GAALMNAMTNR1AMTNR1BCYP2C19 | |
| SCHEMBL11884465 | 0.80 | PARP10 (0.45) | PARP10KMT2AMEN1POLBCTNNB1 | |
| SCHEMBL10971334 | 0.78 | MTNR1A (0.41) | KMT2AMEN1GAAALDH1A1LMNA | |
| SCHEMBL5214433 | 0.78 | PARP10 (0.44) | PARP10KMT2AMEN1POLBCTNNB1 | |
| SCHEMBL4580738 | 0.77 | PARP10 (0.42) | PARP10KMT2AMEN1POLBCTNNB1 | |
| SCHEMBL11514680 | 0.77 | CES2 (0.50) | KMT2AMEN1ALDH1A1LMNATP53 | |
| SCHEMBL28319983 | 0.77 | PARP10 (0.42) | PARP10KMT2AMEN1POLBCTNNB1 | |
| SCHEMBL7408531 | 0.77 | PARP10 (0.42) | PARP10KMT2AMEN1POLBCTNNB1 | |
| SCHEMBL2007632 | 0.77 | PARP10 (0.42) | PARP10KMT2AMEN1POLBCTNNB1 | |
| SCHEMBL995776 | 0.77 | LDHA (0.52) | PARP10KMT2AMEN1POLBCTNNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 85 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0575556-A4 | PALYTOXIN-RELATED PRODRUGS AND A METHOD FOR THEIR ADMINISTRATION. | HAWAII BIOTECH GROUP (US) | 1994-03-21 | — | — | EP | claimed |
| EP-0575556-A1 | PALYTOXIN-RELATED PRODRUGS AND A METHOD FOR THEIR ADMINISTRATION | HAWAII BIOTECHNOLOGY GROUP, INC. (US) | 1993-12-29 | — | — | EP | claimed |
| WO-1992016203-A1 | PALYTOXIN-RELATED PRODRUGS AND A METHOD FOR THEIR ADMINISTRATION | HAWAII BIOTECHNOLOGY GROUP, INC. (US) | 1992-10-01 | — | — | WO | claimed |
| EP-2753345-B1 | POLYPEPTIDE VACCINE | AGENCY SCIENCE TECH & RES (SG) | 2016-07-13 | — | — | EP | disclosed |
| WO-2014181085-A1 | TUMOUR THERAPY | BAGSHAWE KENNETH DAWSON (GB) | 2014-11-13 | — | — | WO | disclosed |
| US-8728470-B2 | CAB molecules | DANISCO US INC. (US) | 2014-05-20 | — | — | US | disclosed |
| EP-1877102-B1 | TAB MOLECULES | DANISCO US INC (US) | 2014-05-07 | — | — | EP | disclosed |
| WO-2013036201-A1 | POLYPEPTIDE VACCINE | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2013-03-14 | — | — | WO | disclosed |
| EP-2506864-A1 | TREATMENT AND PREVENTION OF CANCERS ASSOCIATED WITH INTRACELLULAR ONCOPROTEINS BY ANTIBODY THERAPY OR VACCINATION | Agency For Science, Technology And Research (SG) | 2012-10-10 | — | — | EP | disclosed |
| US-8188240-B2 | Tab molecules | DANISCO US INC. (US) | 2012-05-29 | — | — | US | disclosed |
| US-20120107314-A1 | CAB MOLECULES | DANISCO US INC. | 2012-05-03 | — | — | US | disclosed |
| EP-0746336-A4 | PRODRUGS ACTIVATED BY TARGETED CATALYTIC PROTEINS | IGEN INC (US) | 1996-07-26 | — | — | EP | disclosed |
| EP-0302473-B1 | Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells | BRISTOL MYERS SQUIBB CO (US) | 1995-02-15 | — | — | EP | disclosed |
| EP-0575556-A4 | PALYTOXIN-RELATED PRODRUGS AND A METHOD FOR THEIR ADMINISTRATION. | HAWAII BIOTECH GROUP (US) | 1994-03-21 | — | — | EP | disclosed |
| EP-0575556-A1 | PALYTOXIN-RELATED PRODRUGS AND A METHOD FOR THEIR ADMINISTRATION | HAWAII BIOTECHNOLOGY GROUP, INC. (US) | 1993-12-29 | — | — | EP | disclosed |
| EP-0540859-A1 | Anthracycline prodrugs | Bristol-Myers Squibb Company (US) | 1993-05-12 | — | — | EP | disclosed |
| WO-1993002703-A1 | PRODRUGS ACTIVATED BY TARGETED CATALYTIC PROTEINS | IGEN, INC. (US) | 1993-02-18 | — | — | WO | disclosed |
| WO-1992016203-A1 | PALYTOXIN-RELATED PRODRUGS AND A METHOD FOR THEIR ADMINISTRATION | HAWAII BIOTECHNOLOGY GROUP, INC. (US) | 1992-10-01 | — | — | WO | disclosed |
| US-4975278-A | Converting the prodrug at the tumor site to the active drug by means of the conjugate bound to a tumor surface antigen | BRISTOL-MYERS COMPANY (US) | 1990-12-04 | — | — | US | disclosed |
| EP-0302473-A2 | Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells | Bristol-Myers Squibb Company (US) | 1989-02-08 | — | — | EP | disclosed |