Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 4/20 | 0.40 |
| ▸ | CA2 | P00918 | 4/20 | 0.40 |
| ▸ | CA4 | P22748 | 4/20 | 0.40 |
| ▸ | CA9 | Q16790 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | G6PD | P11413 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3135296 | 0.78 | CCR1 (0.41) | — | |
| SCHEMBL1703906 | 0.75 | SIGMAR1 (0.47) | CA1CA2CA4CA9LMNA | |
| SCHEMBL2007646 | 0.74 | PDK1 (0.51) | SIGMAR1 | |
| SCHEMBL1188918 | 0.74 | MEN1 (0.48) | SIGMAR1ALDH1A1AGTR2GAA | |
| SCHEMBL3491620 | 0.74 | CA1 (0.65) | CA1CA2CA4CA9LMNA | |
| SCHEMBL14714339 | 0.74 | CA1 (0.65) | CA1CA2CA4CA9LMNA | |
| SCHEMBL15279940 | 0.74 | CA1 (0.65) | CA1CA2CA4CA9LMNA | |
| SCHEMBL1713773 | 0.73 | CA1 (0.52) | CA1CA2CA4CA9SIGMAR1 | |
| SCHEMBL4290992 | 0.72 | CA1 (0.56) | CA1CA2CA4CA9LMNA | |
| SCHEMBL28429512 | 0.71 | SIGMAR1 (0.54) | CA1CA2CA4CA9LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7964602-B2 | Biaryl compounds useful as agonists of the Gpr38 receptor | GLAXO GROUP LIMITED (GB) | 2011-06-21 | — | — | US | disclosed |