Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 13/20 | 0.39 |
| ▸ | KLRK1 | P26718 | 1/20 | 0.36 |
| ▸ | MICA | Q29983 | 1/20 | 0.36 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.34 |
| ▸ | ACP1 | P24666 | 1/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20077327 | 0.92 | ITGB3 (0.40) | GPR119KLRK1MICAAVPR2ITGB3 | |
| SCHEMBL20077051 | 0.88 | GPR119 (0.38) | GPR119 | |
| SCHEMBL22894953 | 0.83 | NR1H2 (0.42) | GPR119AVPR2 | |
| SCHEMBL22894955 | 0.83 | NR1H2 (0.42) | GPR119AVPR2 | |
| SCHEMBL22894982 | 0.83 | GPR119 (0.43) | GPR119AVPR2ITGB3ITGA2BACP1 | |
| SCHEMBL20077650 | 0.82 | ITGB3 (0.39) | GPR119AVPR2ITGB3ITGA2BACP1 | |
| SCHEMBL20077312 | 0.79 | GPR119 (0.60) | GPR119 | |
| SCHEMBL22894988 | 0.79 | NR1H2 (0.44) | GPR119AVPR2ITGB3ITGA2BACP1 | |
| SCHEMBL20077328 | 0.79 | NR1H2 (0.44) | GPR119AVPR2ITGB3ITGA2BACP1 | |
| SCHEMBL22894951 | 0.78 | NR1H2 (0.51) | GPR119AVPR2ITGB3ITGA2BACP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018068296-A1 | PIPERIDINE DERIVATIVES AS LIVER X RECEPTOR β AGONISTS, COMPOSITIONS, AND THEIR USE | MERCK SHARP & DOHME CORP. (US) | 2018-04-19 | — | — | WO | disclosed |
| WO-2018071315-A2 | PIPERIDINE DERIVATIVES AS LIVER X RECEPTOR BETA AGONISTS, COMPOSITIONS, AND THEIR USE | MERCK SHARP & DOHME CORP. (US) | 2018-04-19 | — | — | WO | disclosed |