Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 2/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.38 |
| ▸ | F10 | P00742 | 4/20 | 0.38 |
| ▸ | AVPR2 | P30518 | 2/20 | 0.38 |
| ▸ | ACP1 | P24666 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 2/20 | 0.37 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 2/20 | 0.36 |
| ▸ | PLG | P00747 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20077327 | 0.90 | ITGB3 (0.40) | ITGB3ITGA2BGPR119F10AVPR2 | |
| SCHEMBL22894972 | 0.83 | NR1H2 (0.51) | ITGB3ITGA2BGPR119AVPR2ACP1 | |
| SCHEMBL20077563 | 0.83 | NR1H2 (0.51) | ITGB3ITGA2BGPR119AVPR2ACP1 | |
| SCHEMBL20077088 | 0.82 | GPR119 (0.39) | ITGB3ITGA2BGPR119AVPR2ACP1 | |
| SCHEMBL20077051 | 0.81 | GPR119 (0.38) | GPR119RAB9A | |
| SCHEMBL20060931 | 0.78 | HCRTR1 (0.39) | GPR119 | |
| SCHEMBL20060844 | 0.77 | GPR119 (0.46) | GPR119 | |
| SCHEMBL22310514 | 0.75 | GPR119 (0.41) | GPR119RAB9ANAMPT | |
| SCHEMBL20061055 | 0.75 | GPR119 (0.47) | GPR119 | |
| SCHEMBL20060927 | 0.75 | GPR119 (0.47) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018068296-A1 | PIPERIDINE DERIVATIVES AS LIVER X RECEPTOR β AGONISTS, COMPOSITIONS, AND THEIR USE | MERCK SHARP & DOHME CORP. (US) | 2018-04-19 | — | — | WO | disclosed |