Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.48 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.44 |
| ▸ | KCNN4 | O15554 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20077094 | 0.85 | LMNA (0.53) | MAPTKMT2AHDAC3HDAC4HDAC1 | |
| SCHEMBL13255792 | 0.83 | HDAC3 (0.47) | MAPTKMT2AHDAC3HDAC4HDAC1 | |
| SCHEMBL17055297 | 0.81 | EPHX2 (0.46) | MAPTKMT2AHDAC3HDAC4HDAC1 | |
| SCHEMBL14678138 | 0.81 | RIPK1 (0.65) | MAPTKMT2ARIPK1CYP2C19LMNA | |
| SCHEMBL3987037 | 0.81 | POLB (0.42) | KMT2AHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL24671951 | 0.81 | HTT (0.60) | MAPTKMT2AHDAC3HDAC4HDAC1 | |
| SCHEMBL5068146 | 0.78 | HDAC3 (0.42) | KMT2AHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL9035777 | 0.78 | HDAC3 (0.70) | MAPTKMT2AHDAC3HDAC4HDAC1 | |
| SCHEMBL13270940 | 0.78 | MAPT (0.57) | MAPTKMT2AHDAC3HDAC4HDAC1 | |
| SCHEMBL22146016 | 0.78 | OPRK1 (0.51) | MAPTKMT2AHDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071315-A2 | PIPERIDINE DERIVATIVES AS LIVER X RECEPTOR BETA AGONISTS, COMPOSITIONS, AND THEIR USE | MERCK SHARP & DOHME CORP. (US) | 2018-04-19 | — | — | WO | disclosed |