Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 2/20 | 0.52 |
| ▸ | RXRA | P19793 | 1/20 | 0.52 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.52 |
| ▸ | CDK2 | P24941 | 1/20 | 0.52 |
| ▸ | RXRB | P28702 | 1/20 | 0.52 |
| ▸ | RXRG | P48443 | 1/20 | 0.52 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | POLA1 | P09884 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.42 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15603520 | 0.83 | KARS1 (0.55) | KARS1RXRACCNE1CDK2RXRB | |
| SCHEMBL15603503 | 0.83 | KARS1 (0.55) | KARS1RXRACCNE1CDK2RXRB | |
| SCHEMBL15603521 | 0.83 | KARS1 (0.55) | KARS1RXRACCNE1CDK2RXRB | |
| SCHEMBL20077284 | 0.75 | POLA1 (0.47) | KARS1RXRACCNE1CDK2RXRB | |
| SCHEMBL13111981 | 0.73 | NR1I2 (0.71) | KARS1RXRACCNE1CDK2RXRB | |
| SCHEMBL15603506 | 0.71 | KARS1 (0.47) | KARS1RXRACCNE1CDK2RXRB | |
| SCHEMBL15604548 | 0.71 | POLA1 (0.51) | KARS1RXRACCNE1CDK2RXRB | |
| SCHEMBL15604551 | 0.71 | POLA1 (0.51) | KARS1RXRACCNE1CDK2RXRB | |
| SCHEMBL15604565 | 0.71 | POLA1 (0.51) | KARS1RXRACCNE1CDK2RXRB | |
| SCHEMBL151743 | 0.70 | KARS1 (0.56) | KARS1RXRACCNE1CDK2RXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10000438-B2 | Small molecule inhibitors of TRPA1 | B.R.A.I.N. BIOTECHNOLOGY RESEARCH AND INFORMATION NETWORK AG (DE) | 2018-06-19 | — | — | US | disclosed |
| US-20180105482-A9 | SMALL MOLECULE INHIBITORS OF TRPA1 | B.R.A.I.N. BIOTECHNOLOGY RESEARCH AND INFORMATION NETWORK AG (DE) | 2018-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10000438-B2 | Small molecule inhibitors of TRPA1 | TRPA1, TRPV1, TRPV2 | KARS1 3860/4885RXRA 2796/4885CCNE1 4567/4885 |
| US-20180105482-A9 | SMALL MOLECULE INHIBITORS OF TRPA1 | TRPA1, TRPV1, TRPV2 | KARS1 3860/4885RXRA 2796/4885CCNE1 4567/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.