Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | TSHR | P16473 | 3/20 | 0.62 |
| ▸ | S1PR2 | O95136 | 6/20 | 0.50 |
| ▸ | S1PR1 | P21453 | 6/20 | 0.50 |
| ▸ | S1PR3 | Q99500 | 6/20 | 0.50 |
| ▸ | S1PR4 | O95977 | 5/20 | 0.50 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.50 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.44 |
| ▸ | ADH1B | P00325 | 1/20 | 0.44 |
| ▸ | ADH1C | P00326 | 1/20 | 0.44 |
| ▸ | ADH1A | P07327 | 1/20 | 0.44 |
| ▸ | ADH4 | P08319 | 1/20 | 0.44 |
| ▸ | ADH7 | P40394 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | ANPEP | P15144 | 1/20 | 0.40 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27174200 | 1.00 | ALDH1A1 (0.62) | ALDH1A1TSHRS1PR2S1PR1S1PR3 | |
| SCHEMBL20878393 | 1.00 | ALDH1A1 (0.62) | ALDH1A1TSHRS1PR2S1PR1S1PR3 | |
| SCHEMBL19509413 | 1.00 | ALDH1A1 (0.62) | ALDH1A1TSHRS1PR2S1PR1S1PR3 | |
| SCHEMBL27174196 | 1.00 | ALDH1A1 (0.62) | ALDH1A1TSHRS1PR2S1PR1S1PR3 | |
| SCHEMBL1532553 | 1.00 | ALDH1A1 (0.62) | ALDH1A1TSHRS1PR2S1PR1S1PR3 | |
| SCHEMBL27174199 | 1.00 | ALDH1A1 (0.62) | ALDH1A1TSHRS1PR2S1PR1S1PR3 | |
| SCHEMBL27425878 | 0.98 | ALDH1A1 (0.65) | ALDH1A1TSHRS1PR2S1PR1S1PR3 | |
| SCHEMBL11589699 | 0.91 | TSHR (0.62) | ALDH1A1TSHRS1PR2S1PR1S1PR3 | |
| SCHEMBL16509666 | 0.91 | TSHR (0.62) | ALDH1A1TSHRS1PR2S1PR1S1PR3 | |
| SCHEMBL800624 | 0.90 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10259810-B2 | N-sulfonylated pyrazolo[3,4-b]pyridin-6-carboxamides and method of use | AbbVie S.à.r.l. (LU) | 2019-04-16 | — | — | US | disclosed |
| US-20180105522-A1 | N-SULFONYLATED PYRAZOLO[3,4-b]PYRIDIN-6-CARBOXAMIDES AND METHOD OF USE | GALAPAGOS SASU (FR) | 2018-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10259810-B2 | N-sulfonylated pyrazolo[3,4-b]pyridin-6-carboxamides and method of use | CFTR, P2RY1, P2RX5 | ALDH1A1 3001/4885TSHR 210/4885S1PR2 141/4885 |
| US-20180105522-A1 | N-SULFONYLATED PYRAZOLO[3,4-b]PYRIDIN-6-CARBOXAMIDES AND METHOD OF USE | CFTR, P2RY1, P2RX5 | ALDH1A1 3001/4885TSHR 210/4885S1PR2 141/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.