Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.57 |
| ▸ | ATG4B | Q9Y4P1 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.57 |
| ▸ | RELA | Q04206 | 1/20 | 0.57 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.54 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4249088 | 0.84 | PBRM1 (0.75) | ALDH1A1MAPTPLA2G1BATG4BPBRM1 | |
| SCHEMBL30575470 | 0.84 | PBRM1 (0.75) | ALDH1A1MAPTPLA2G1BATG4BPBRM1 | |
| SCHEMBL28297347 | 0.82 | PBRM1 (0.73) | ALDH1A1MAPTPLA2G1BATG4BPBRM1 | |
| SCHEMBL5357396 | 0.80 | FABP4 (0.65) | ALDH1A1MAPTKMT2AAKR1C3MEN1 | |
| SCHEMBL1908399 | 0.80 | MAPK13 (0.55) | ALDH1A1MAPTSMN1; SMN2NPC1HTT | |
| SCHEMBL17663805 | 0.80 | MAPK14 (0.65) | ALDH1A1MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL27529702 | 0.80 | MAPK14 (0.78) | ALDH1A1MAPTSMN1; SMN2PLA2G1BATG4B | |
| SCHEMBL20077656 | 0.79 | MAPK13 (0.66) | ALDH1A1MAPTNPC1RAB9AKDM4E | |
| SCHEMBL49873 | 0.79 | KMT2A (0.65) | ALDH1A1MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL29434816 | 0.79 | KMT2A (0.65) | ALDH1A1MAPTSMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10208001-B2 | Process for preparing 1,4-dibenzodiazepines via Buchwald-Hartwig chemistry | UNIVERSIDADE DE EVORA (PT) | 2019-02-19 | — | — | US | disclosed |
| US-20180105502-A1 | PROCESS FOR PREPARING 1,4-DIBENZODIAZEPINES VIA BUCHWALD-HARTWIG CHEMISTRY | UNIVERSIDADE DE EVORA (PT) | 2018-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10208001-B2 | Process for preparing 1,4-dibenzodiazepines via Buchwald-Hartwig chemistry | HRH2, HRH4, HRH1 | ALDH1A1 235/4885MAPT 4241/4885SMN1; SMN2 3533/4885 |
| US-20180105502-A1 | PROCESS FOR PREPARING 1,4-DIBENZODIAZEPINES VIA BUCHWALD-HARTWIG CHEMISTRY | HRH2, HRH4, HRH1 | ALDH1A1 235/4885MAPT 4241/4885SMN1; SMN2 3533/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.