Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1C | Q13936 | 2/20 | 0.42 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.42 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.42 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20077744 | 0.84 | KDM4E (0.41) | CACNA1CCACNA1FCACNA1DCACNA1SKDM4E | |
| SCHEMBL31114599 | 0.71 | GABRP (0.49) | CACNA1CCACNA1FCACNA1DCACNA1SKDM4E | |
| SCHEMBL20568124 | 0.71 | ABL1 (0.48) | KDM4EALDH1A1TDP1LMNAHPGD | |
| SCHEMBL21510772 | 0.70 | KDM4E (0.40) | CACNA1CKDM4EALDH1A1GAAKMT2A | |
| SCHEMBL20077894 | 0.70 | KDM4E (0.42) | CACNA1CKDM4EALDH1A1GAAKMT2A | |
| SCHEMBL16549400 | 0.70 | POLB (0.50) | CACNA1CKDM4EALDH1A1GAAKMT2A | |
| SCHEMBL20077988 | 0.69 | ALDH1A1 (0.45) | CACNA1CCACNA1FCACNA1DCACNA1SKDM4E | |
| SCHEMBL16549389 | 0.69 | KDM4E (0.56) | CACNA1CCACNA1FCACNA1DCACNA1SKDM4E | |
| SCHEMBL22077851 | 0.68 | S1PR1 (0.55) | KDM4EALDH1A1L3MBTL1NPC1LMNA | |
| SCHEMBL700154 | 0.68 | KDM4E (0.51) | KDM4EALDH1A1GAAKMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190322644-A1 | HETEROCYCLIC APELIN RECEPTOR (APJ) AGONISTS AND USES THEREOF | RESEARCH TRIANGLE INSTITUTE | 2019-10-24 | — | — | US | disclosed |
| WO-2018071526-A1 | HETEROCYCLIC APELIN RECEPTOR (APJ) AGONISTS AND USES THEREOF | RESEARCH TRIANGLE INSTITUTE (US) | 2018-04-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190322644-A1 | HETEROCYCLIC APELIN RECEPTOR (APJ) AGONISTS AND USES THEREOF | APLNR, GRPR, BID | CACNA1C 757/4885CACNA1F 1483/4885CACNA1D 909/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.