Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC5A1 | P13866 | 1/20 | 0.51 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | RBP4 | P02753 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14357211 | 0.87 | SLC5A1 (0.50) | SLC5A1SLC5A2KMT2ARXFP1GAA | |
| SCHEMBL3698071 | 0.84 | NPSR1 (0.57) | KMT2ARXFP1GAATP53POLB | |
| SCHEMBL538328 | 0.84 | MAPT (0.54) | KMT2ARXFP1GAATP53POLB | |
| SCHEMBL20077903 | 0.82 | KMT2A (0.48) | SLC5A1SLC5A2KMT2ARXFP1GAA | |
| SCHEMBL2843332 | 0.81 | PDE4B (0.60) | KMT2AGAATP53POLBMAPT | |
| SCHEMBL2320551 | 0.81 | RBP4 (0.47) | KMT2AMAPTALDH1A1RBP4MEN1 | |
| SCHEMBL952061 | 0.81 | FAAH (0.53) | KMT2ARXFP1GAATP53POLB | |
| SCHEMBL3708992 | 0.80 | TP53 (0.51) | KMT2ARXFP1GAATP53POLB | |
| SCHEMBL3695919 | 0.80 | TP53 (0.51) | KMT2ARXFP1GAATP53POLB | |
| SCHEMBL14473680 | 0.80 | KMT2A (0.47) | KMT2ARXFP1GAATP53POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190322644-A1 | HETEROCYCLIC APELIN RECEPTOR (APJ) AGONISTS AND USES THEREOF | RESEARCH TRIANGLE INSTITUTE | 2019-10-24 | — | — | US | disclosed |
| WO-2018071526-A1 | HETEROCYCLIC APELIN RECEPTOR (APJ) AGONISTS AND USES THEREOF | RESEARCH TRIANGLE INSTITUTE (US) | 2018-04-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190322644-A1 | HETEROCYCLIC APELIN RECEPTOR (APJ) AGONISTS AND USES THEREOF | APLNR, GRPR, BID | SLC5A1 3557/4885SLC5A2 3158/4885KMT2A 3585/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.