Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.43 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL760035 | 1.00 | ALDH1A1 (0.50) | ALDH1A1TSHRTHRBMEN1KMT2A | |
| SCHEMBL26192643 | 1.00 | ALDH1A1 (0.50) | ALDH1A1TSHRTHRBMEN1KMT2A | |
| SCHEMBL8024528 | 1.00 | ALDH1A1 (0.50) | ALDH1A1TSHRTHRBMEN1KMT2A | |
| SCHEMBL862847 | 0.96 | — | — | |
| SCHEMBL19309079 | 0.91 | MEN1 (0.56) | ALDH1A1TSHRMEN1KMT2AMAPK1 | |
| SCHEMBL5155263 | 0.91 | MEN1 (0.56) | ALDH1A1TSHRMEN1KMT2AMAPK1 | |
| SCHEMBL12893042 | 0.89 | SMN1; SMN2 (0.41) | ALDH1A1TSHRTHRBMEN1KMT2A | |
| SCHEMBL14924288 | 0.89 | SMN1; SMN2 (0.41) | ALDH1A1TSHRTHRBMEN1KMT2A | |
| SCHEMBL13113468 | 0.89 | ALDH1A1 (0.41) | ALDH1A1TSHRTHRBMEN1KMT2A | |
| SCHEMBL5157716 | 0.89 | MAPK1 (0.55) | ALDH1A1TSHRMEN1KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020264490-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2020-12-30 | — | — | WO | disclosed |
| US-9950078-B2 | Pyrrolobenzodiazepine-antibody conjugates | MEDIMMUNE LIMITED (GB) | 2018-04-24 | — | — | US | disclosed |
| US-9950078-B2 | Pyrrolobenzodiazepine-antibody conjugates | MEDIMMUNE LIMITED (GB) | 2018-04-24 | — | — | US | disclosed |