Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 8/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | XBP1 | P17861 | 1/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17039174 | 0.84 | ACACB (0.50) | ACACBMAPTTP53KMT2AMEN1 | |
| SCHEMBL17039176 | 0.83 | MMP2 (0.51) | ACACBMAPTTP53KMT2AMEN1 | |
| SCHEMBL20878717 | 0.83 | ACACB (0.47) | ACACBMAPTTP53KMT2AMEN1 | |
| SCHEMBL14679174 | 0.77 | MAPT (0.66) | ACACBMAPTTP53KMT2AALDH1A1 | |
| SCHEMBL17039179 | 0.76 | MMP2 (0.67) | ACACB | |
| SCHEMBL20078580 | 0.75 | ACACB (0.47) | ACACBMAPTTP53KMT2AMEN1 | |
| SCHEMBL16375378 | 0.75 | MAPT (0.52) | ACACBMAPTTP53KMT2AMEN1 | |
| SCHEMBL4516428 | 0.74 | GPR119 (0.53) | ACACBMAPTTP53KMT2AMEN1 | |
| SCHEMBL29471397 | 0.74 | MAPT (0.61) | MAPTTP53KMT2ASMN1; SMN2PKM | |
| SCHEMBL8279808 | 0.73 | MAPT (0.50) | ACACBMAPTTP53KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9951035-B2 | Selective matrix metalloproteinase inhibitors | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2018-04-24 | — | — | US | disclosed |