Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 8/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | XBP1 | P17861 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17026736 | 0.87 | ACACB (0.53) | ACACBMAPTTP53KMT2AMEN1 | |
| SCHEMBL20078579 | 0.84 | ACACB (0.48) | ACACBMAPTTP53KMT2AMEN1 | |
| SCHEMBL17039175 | 0.80 | SDCBP (0.47) | MAPTALDH1A1TDP1HDAC1 | |
| SCHEMBL14679174 | 0.78 | MAPT (0.66) | ACACBMAPTTP53KMT2AALDH1A1 | |
| SCHEMBL28346545 | 0.78 | MAPT (0.45) | ACACBMAPTTP53KMT2AMEN1 | |
| SCHEMBL4516428 | 0.76 | GPR119 (0.53) | ACACBMAPTTP53KMT2AMEN1 | |
| SCHEMBL29471397 | 0.75 | MAPT (0.61) | MAPTTP53KMT2ASMN1; SMN2PKM | |
| SCHEMBL1106583 | 0.74 | MAPT (0.50) | ACACBMAPTTP53KMT2AMEN1 | |
| SCHEMBL8279808 | 0.74 | MAPT (0.50) | ACACBMAPTTP53KMT2AMEN1 | |
| SCHEMBL17039176 | 0.74 | MMP2 (0.51) | ACACBMAPTTP53KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9951035-B2 | Selective matrix metalloproteinase inhibitors | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2018-04-24 | — | — | US | disclosed |
| US-9951035-B2 | Selective matrix metalloproteinase inhibitors | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2018-04-24 | — | — | US | disclosed |
| US-20170190685-A1 | SELECTIVE MATRIX METALLOPROTEINASE INHIBITORS | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2017-07-06 | — | — | US | disclosed |
| US-20170190685-A1 | SELECTIVE MATRIX METALLOPROTEINASE INHIBITORS | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2017-07-06 | — | — | US | disclosed |
| US-9604957-B2 | Selective matrix metalloproteinase inhibitors | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2017-03-28 | — | — | US | disclosed |
| US-9604957-B2 | Selective matrix metalloproteinase inhibitors | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2017-03-28 | — | — | US | disclosed |
| US-20170015647-A1 | SELECTIVE MATRIX METALLOPROTEINASE INHIBITORS | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2017-01-19 | — | — | US | disclosed |
| US-20170015647-A1 | SELECTIVE MATRIX METALLOPROTEINASE INHIBITORS | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2017-01-19 | — | — | US | disclosed |
| WO-2015127302-A1 | SELECTIVE MATRIX METALLOPROTEINASE INHIBITORS | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2015-08-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170190685-A1 | SELECTIVE MATRIX METALLOPROTEINASE INHIBITORS | MMP14, MMP9, MMP13 | ACACB 1373/4885MAPT 1297/4885TP53 3143/4885 |
| US-20170015647-A1 | SELECTIVE MATRIX METALLOPROTEINASE INHIBITORS | MMP14, MMP9, MMP13 | ACACB 1373/4885MAPT 1297/4885TP53 3143/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.