Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | CASR | P41180 | 1/20 | 0.31 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18233548 | 0.77 | LMNA (0.32) | — | |
| SCHEMBL24726521 | 0.66 | TAAR1 (0.42) | PTPN5 | |
| SCHEMBL13524522 | 0.64 | LMNA (0.50) | PDE4APTPN5 | |
| SCHEMBL26378188 | 0.62 | AKR1C3 (0.56) | CASR | |
| SCHEMBL18233547 | 0.62 | LMNA (0.35) | — | |
| SCHEMBL25453297 | 0.60 | CASR (0.51) | CASR | |
| SCHEMBL9289288 | 0.60 | PTGS2 (0.47) | PDE4APDE4BPDE4CPDE4DCASR | |
| SCHEMBL24956787 | 0.59 | LMNA (0.41) | — | |
| SCHEMBL21386081 | 0.59 | NFE2L2 (0.32) | — | |
| SCHEMBL12618445 | 0.58 | LMNA (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9951065-B2 | Benzimidazole and imadazopyridine carboximidamide compounds | GILEAD SCIENCES, INC. (US) | 2018-04-24 | — | — | US | disclosed |