Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.52 |
| ▸ | FYN | P06241 | 3/20 | 0.39 |
| ▸ | JAK2 | O60674 | 4/20 | 0.36 |
| ▸ | JAK3 | P52333 | 4/20 | 0.36 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.33 |
| ▸ | KDR | P35968 | 2/20 | 0.33 |
| ▸ | ACVR2A | P27037 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.33 |
| ▸ | BMP4 | P12644 | 1/20 | 0.33 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.33 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23931665 | 0.90 | AAK1 (0.54) | AAK1FYNJAK2JAK3PTK2 | |
| SCHEMBL30102937 | 0.90 | AAK1 (0.54) | AAK1FYNJAK2JAK3PTK2 | |
| SCHEMBL20081018 | 0.75 | AAK1 (0.50) | AAK1FYNJAK2JAK3PTK2 | |
| SCHEMBL17495348 | 0.74 | AAK1 (0.67) | AAK1JAK2JAK3PTK2TGFBR2 | |
| SCHEMBL29398488 | 0.74 | AAK1 (0.67) | AAK1JAK2JAK3PTK2TGFBR2 | |
| SCHEMBL20081012 | 0.72 | AAK1 (0.69) | AAK1FYNJAK2JAK3PTK2 | |
| SCHEMBL30172473 | 0.72 | AAK1 (0.59) | AAK1FYNJAK2JAK3PTK2 | |
| Hydrochloric Acid SCHEMBL30172429 | 0.72 | BMP4 (0.50) | AAK1JAK2JAK3PTK2PSEN1 | |
| SCHEMBL20081020 | 0.71 | AAK1 (0.80) | AAK1JAK2JAK3PTK2PSEN1 | |
| SCHEMBL19467027 | 0.71 | AAK1 (0.83) | AAK1JAK2JAK3PTK2PSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115427045-A | 4- (3- (pyridin-3-yl) pyrazolo [1,5-a ] pyrimidin-5-yl) piperazine for the treatment of COV-229E or COV-OC43 coronavirus infection | 莱西肯医药有限公司 | 2022-12-02 | — | — | CN | disclosed |